ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Invasive transvalvular flow rate to predict likely severe aortic valve stenosis with low-gradient and normal ejection fraction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThere are limited data on the diagnostic role of invasively measured transvalvular flow rate (TFR) in patients with low-gradient (mean gradient < 40 mmHg) severe aortic valve stenosis (AS) (aortic valve area (AVA) ≤ 1 cm
objectivesTo evaluate the role of invasively measured TFR as a diagnostic tool for likely severe discordant AS in patients with preserved left ventricular ejection fraction (LVEF).
methodsWe included 134 patients from a single-center registry, who had low-gradient, severe AS, and normal LVEF, and underwent pre-TAVI invasive hemodynamic evaluation. Patients were divided into likely and unlikely severe AS according to the latest European Society of Cardiology (ESC) guidelines.
resultsPatients with likely and unlikely severe AS had comparable stroke volume index (SVi) (32.01 ± 9.15 vs. 34.09 ± 11.36 ml/m
conclusionLow invasive TFR is highly associated with the diagnosis of likely severe AS. Likely severe discordant AS with normal LV systolic function showed better long-term outcome after TAVI.
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