Evidence map›Paper›PMID 42230367›Full record

ArticleEJNMMI research2026

The test-retest reproducibility of [

Tanja Sjöros, Markus Matilainen, Virva Saunavaara, Saara Wahlroos, Johan Rajander, Mikko Koivumäki, Eveliina Honkonen, Amelie Luoma, Laura Airas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tanja SjörosTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland. tanja.sjoros@utu.fi.ORCID http://orcid.org/0000-0003-4477-8175
Markus MatilainenTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.
Virva SaunavaaraTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.
Saara WahlroosTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.
Johan RajanderTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.
Mikko KoivumäkiTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.
Eveliina HonkonenTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.
Amelie LuomaTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.
Laura AirasTurku PET Centre, University of Turku, Åbo Akademi University, Turku University Hospital, P.O. Box 52, Turku, 20521, Finland.

Funding

Research Council of Finland 337530Research Council of Finland 357910Research Council of Finland 358823Wellbeing Services County of Southwest Finland Wellbeing Services County of Southwest Finland
6 · The paper itself

Abstract

backgroundPositron emission tomography (PET) imaging of the 18 kDa translocator protein (TSPO) is a method to quantify central inflammation and particularly microglial activation, which is increased in progressive multiple sclerosis (MS) among other neurodegenerative diseases. We evaluated the test-retest reproducibility of TSPO-PET imaging using Biograph Vision Quadra and [

resultsThe ICCs indicated excellent test-retest reproducibility in distinct cortical regions (0.933-0.985) and white matter (0.980), and good to excellent test-retest reproducibility in deep grey matter structures (0.867-0.988). Additionally, the reproducibility was evaluated lesion-wise in the ≥50mm

conclusionThe test-retest reproducibility of [

Indexed as

[11C]PK11195Multiple sclerosisPositron emission tomographyTest-retest reproducibilityTSPO

Identifiers

PMID42230367
PMCPMC13442786

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.