Evidence map›Paper›PMID 42230348›Full record

ReviewInnere Medizin (Heidelberg, Germany)2026

[Rheumatoid arthritis-more than just a joint disease : Overview for internal medicine practice].

Lien Meerkatt, David Simon, Edgar Wiebe

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Innere Medizin (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lien MeerkattKlinik für Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
David SimonKlinik für Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. david.simon@charite.de.
Edgar WiebeKlinik für Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a common chronic inflammatory disease and a systemic autoimmune disorder associated with increased morbidity and mortality due to multiorgan involvement.

objectivesTo summarize pathophysiology, clinical presentation, diagnostics and modern treatment strategies of RA, and to highlight its relevance for internal medicine.

methodsNarrative review of current literature, guidelines and clinical studies with a focus on clinically relevant aspects regarding diagnosis, treatment, and comorbidities.

resultsRA results from a complex interaction of genetic predisposition and immune dysregulation leading to autoantibody formation and chronic inflammation. Clinically, it typically presents as symmetric polyarthritis, although early and atypical manifestations are common. Diagnosis is primarily clinical and is supported by serology and imaging. Early treatment following a treat-to-target strategy with disease-modifying anti-rheumatic drugs (DMARDs) enables remission in many patients. Comorbidities, particularly cardiovascular disease, significantly contribute to disease burden.

conclusionRA requires early recognition, timely initiation of therapy, and interdisciplinary management. Internists play a key role in early diagnosis, risk stratification and long-term care.

Indexed as

Arthritis, RheumatoidInternal MedicineAntirheumatic AgentsAutoantibodiesComorbidityGenetic Predisposition to DiseaseHumansAntirheumatic AgentsAutoantibodiesAnti-citrullinated protein antibodiesAutoantibodiesAutoimmune diseasesInflammationRheumatoid factor

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.