ArticleEndocrinology2026
Conditional replacement of the mouse luteinizing hormone receptor with green fluorescent protein, enabling imaging of cell migration during ovulation.
Article in Endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Interfollicular communication among preovulatory follicles after luteinizing hormone signaling.Endocrinology · 2026Article
- Conditional replacement of the mouse luteinizing hormone receptor with green fluorescent protein, enabling imaging of cell migration during ovulation.Endocrinology · 2026Article
- Conditional replacement of the mouse LH receptor with GFP, enabling imaging of cell migration during ovulation.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To facilitate the investigation of signaling by the luteinizing hormone receptor (LHR), we created a mouse line called Lhr-COIN. This line allows for the conditional replacement of the Lhr coding sequence with enhanced green fluorescent protein (eGFP), resulting in both a conditional knockout line and a reporter line. By breeding these mice with mice expressing Cre recombinase, we generated mice in which either one or both Lhr alleles were replaced with eGFP. Notably, mice in which one Lhr allele in the granulosa cells was replaced with eGFP exhibited normal LH responsiveness. This enabled live imaging of LH-induced migration of LH-receptor-expressing granulosa cells within preovulatory ovarian follicles. The Lhr-COIN mouse line holds significant potential for future research on LHR function and localization in the ovary and other tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.