Evidence map›Paper›PMID 42230143›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Presynaptic Vesicles Supply Membrane for Axonal Bouton Enlargement during Long Term Potentiation.

L M Kirk, G C Garcia, D C Hanka, K Zatyko, T Bartol, T J Sejnowski, K M Harris

Abstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. PyReconstruct: A fully open-source, collaborative successor to Reconstruct.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

L M KirkCenter for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, Texas 78712 lyndskirk@utexas.edu.ORCID https://orcid.org/0000-0002-5125-652X
G C GarciaComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037.
D C HankaCenter for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, Texas 78712.
K ZatykoCenter for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, Texas 78712.
T BartolComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037.
T J SejnowskiComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037.ORCID https://orcid.org/0000-0002-0622-7391
K M HarrisCenter for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, Texas 78712.ORCID https://orcid.org/0000-0002-1943-4744

Funding

Decoding the Heterogeneity of Interneuron Vulnerability in Aging and Alzheimer's Disease: An Ultraplex CLEM ApproachR21AG096582 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KIRK, LYNDSEY M · 2025 to 2025
$439k
NIA NIH HHS R21 AG096582
6 · The paper itself

Abstract

Long-term potentiation (LTP) induces presynaptic bouton enlargement and a reduction in the number of synaptic vesicles. To understand the relationship between these events, we performed 3D analysis of serial section electron micrographs in hippocampal area CA1 from male rats, 2 h after LTP induction. We observed a high vesicle packing density in control boutons, contrasting with a lower density in most LTP boutons. Notably, the summed membrane area of the vesicles lost in low-density LTP boutons is comparable to the surface membrane required for the observed bouton enlargement when compared with high-density control boutons. These novel findings suggest that presynaptic vesicle density provides a new structural indicator of LTP that supports a local mechanism of bouton enlargement.

Indexed as

Long-Term PotentiationPresynaptic TerminalsSynaptic VesiclesAnimalsCA1 Region, HippocampalMaleRatsRats, WistarboutonhippocampusLTPpresynaptic vesiclesynapseultrastructure

Identifiers

PMID42230143
PMCPMC13326708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.