Evidence map›Paper›PMID 42229955›Full record

ArticleBMJ open2026

Treatable Traits for Asthma Management in Pregnancy (TTAP): protocol for an Australian multicentre prospective observational cohort study.

Jane E Grehan, Janet Bristow, Kelly Steel, Bronwyn K Brew, Michael J Peek, Annelies L Robijn, Helen L Barrett, Sean Seeho, Penelope Fotheringham, Marjorie Atchan and 18 more

Abstract read
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In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Jane E GrehanCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia jane.grehan@newcastle.edu.au.ORCID http://orcid.org/0009-0005-2590-8618
Janet BristowCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Kelly SteelCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Bronwyn K BrewCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Michael J PeekReproduction and Perinatal Centre, The University of Sydney, Sydney, New South Wales, Australia.
Annelies L RobijnCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Helen L BarrettUniversity of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-7141-2086
Sean SeehoReproduction and Perinatal Centre, The University of Sydney, Sydney, New South Wales, Australia.
Penelope FotheringhamCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Marjorie AtchanUniversity of Canberra, Canberra, Australian Capital Territory, Australia.
Soriah M HarveyCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Sameh R N SamuelWollongong Hospital, Wollongong, New South Wales, Australia.
Vanessa M McDonaldCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Megan E JensenCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Elizabeth G HollidayCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4066-6224
Megan ReesThe University of Melbourne, Melbourne, Victoria, Australia.
Elissa ElvidgeCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0002-1729-731X
Lesley ViningWollongong Hospital, Wollongong, New South Wales, Australia.
Kathleen ChapmanHunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
Esha JoshiCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.
Andrew C JonesWollongong Hospital, Wollongong, New South Wales, Australia.
Rebekah BowmanUniversity of Canberra, Canberra, Australian Capital Territory, Australia.
Christopher J BreretonWollongong Hospital, Wollongong, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8302-702X
Sarah Al PriceThe University of Melbourne, Melbourne, Victoria, Australia.
Kelly A McNamaraCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0002-7512-1072
Amanda BeechUniversity of New South Wales, Sydney, New South Wales, Australia.
Craig E PennellCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0002-0937-6165
Vanessa E MurphyCollege of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3282-1324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAsthma is one of the most prevalent long-term health conditions affecting pregnant women. Poorly controlled asthma during pregnancy is associated with adverse maternal and fetal outcomes and may predispose offspring to long-term respiratory morbidity. The current 'one size fits all' approach to asthma management during pregnancy is not optimally effective for approximately half of the pregnant women with asthma. A personalised medicine approach to managing airways disease is required. The treatable traits approach focuses on the identification and treatment of traits in the pulmonary, extra-pulmonary and behavioural domains, which are identifiable, measurable, clinically relevant (linked to exacerbation risk or poor asthma control) and treatable. This manuscript outlines the protocol for the Treatable Traits for Asthma Management in Pregnancy (TTAP) study. The purpose of the TTAP study is to prospectively determine the prevalence of a range of treatable traits from these three domains in pregnant women with asthma and determine which traits are associated with exacerbation risk, poor asthma control and poor asthma-related quality of life. Additionally, this study will assess differences in trait prevalence and clinical relevance in pregnant women from regional versus metropolitan hospitals in Australia and in different antenatal models of care. METHODS AND ANALYSIS: The TTAP study is a multicentre, prospective observational cohort study. Study participants are pregnant women with asthma attending antenatal clinics at 10 metropolitan and regional hospitals (public and private) in NSW and Victoria, Australia. Assessment of traits from the pulmonary, extrapulmonary and behavioural domains as well as asthma outcomes is conducted at three gestational timepoints: 12-16 weeks, 22-26 weeks and 32-36 weeks of pregnancy. A follow-up assessment of asthma outcomes is conducted at 2-4 weeks postpartum. The outcomes assessed are asthma exacerbations requiring medical intervention (primary outcome), asthma symptom control and asthma-related quality of life. Traits and outcomes will be assessed using questionnaires, direct questioning, measurement of biomarkers, physical measurements and assessment of routinely collected data from medical records. ETHICS AND DISSEMINATION: The Hunter New England Human Ethics Committee (2024/ETH01289) has approved the TTAP study protocol. Outcomes will be published in peer-reviewed journals, presented at scientific conferences and disseminated online to participants, clinicians and other pregnant women with asthma and their families via the Asthma in Pregnancy Toolkit website https://asthmapregnancytoolkit.org.au/.

Indexed as

AsthmaPregnancy ComplicationsAdultAustraliaFemaleHumansMulticenter Studies as TopicObservational Studies as TopicPregnancyPrenatal CareProspective StudiesQuality of LifeResearch DesignAsthmaPregnancyPregnant WomenProspective studies

Identifiers

PMID42229955
PMCPMC13239357

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.