Evidence map›Paper›PMID 42229805›Full record

ArticleThe Journal of biological chemistry2026

The carbohydrate-binding module of TrCel7A aids in navigating hemicellulose barriers in plant cell walls.

Nerya Zexer, Alec Paradiso, Anuleka Dutta, Daguan Nong, Gabriel Valentin, Parveen Kumar Deralia, Paul Dupree, William O Hancock, Charles T Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nerya ZexerDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Alec ParadisoDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Anuleka DuttaDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Daguan NongDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
Gabriel ValentinDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
Parveen Kumar DeraliaDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Paul DupreeDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
William O HancockDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.
Charles T AndersonDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, USA. Electronic address: cta3@psu.edu.

Funding

NSF 2301377
6 · The paper itself

Abstract

Efficient enzymatic deconstruction of plant cell walls is critical for the utilization of lignocellulose biomass. Key enzymes in this process are cellobiohydrolases, a class of cellulases that processively degrade crystalline cellulose. Many cellobiohydrolases possess a carbohydrate-binding module (CBM), yet the specific roles of CBMs in substrate interaction remains unclear. Here, we use single-molecule fluorescence microscopy to investigate how CBM1 of Trichoderma reesei Cel7A influences enzyme binding and motility on cellulose substrates of varying complexity. We compare WT Cel7A with a truncated variant lacking CBM1 (Cel7A

Indexed as

Cellulose 1,4-beta-CellobiosidaseCell WallPlant CellsPolysaccharidesTrichodermaCarbohydrate Binding ModulesHypocrealesCellulose 1,4-beta-CellobiosidasehemicellulosePolysaccharidescarbohydrate-binding module (CBM)cellulasecelluloselignocellulose deconstructionplant cell wallssingle-molecule microscopy

Identifiers

PMID42229805
PMCPMC13315674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.