Evidence map›Paper›PMID 42229742›Full record

ArticleExperimental neurology2026

Etiology-specific trajectories of longitudinal functional connectivity and network topology in posttraumatic and mesial temporal lobe epileptogenesis.

Nastaran Jafari, Hsiang J Yeh, Udaya Kumar, Neil G Harris, John M Stern, Jerome Engel, Anatol Bragin, Lin Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Nastaran JafariDepartment of Biomedical Engineering, University of North Texas, TX, USA.
Hsiang J YehDepartment of Neurology, University of California Los Angeles, CA, USA.
Udaya KumarDepartment of Neurology, University of California Los Angeles, CA, USA.
Neil G HarrisBrain Research Institute, University of California Los Angeles, CA, USA; UCLA Brain Injury Research Center, Department of Neurosurgery, University of California Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behavior, Intellectual Development and Disabilities Research Center, University of California Los Angeles, CA, USA.
John M SternDepartment of Neurology, University of California Los Angeles, CA, USA.
Jerome EngelDepartment of Neurology, University of California Los Angeles, CA, USA; Brain Research Institute, University of California Los Angeles, CA, USA; Department of Neurobiology and Psychiatry, University of California Los Angeles, CA, USA.
Anatol BraginDepartment of Neurology, University of California Los Angeles, CA, USA; Brain Research Institute, University of California Los Angeles, CA, USA.
Lin LiDepartment of Biomedical Engineering, University of North Texas, TX, USA; Department of Neurology, University of California Los Angeles, CA, USA. Electronic address: lin.li@unt.edu.

Funding

New Electrographic Biomarkers of EpileptogenesisR01NS065877 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAGIN, ANATOL · 2010 to 2018
$4.0M
In Vivo Studies of the Epileptic HippocampusRF1NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, STABA, RICHARD · 2023 to 2023
$3.6M
Strategy to Potentiate Rehabilitation after TBIR01NS116383 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRIS, NEIL · 2021 to 2025
$3.0M
New approach for identification pHFO networks to predict epileptogenesisR16NS131108 · NINDS · UNIVERSITY OF NORTH TEXAS · PI Lin Li · 2022 to 2026
$1.3M
NINDS NIH HHS R01 NS065877NINDS NIH HHS R01 NS116383NINDS NIH HHS R16 NS131108NINDS NIH HHS RF1 NS033310
6 · The paper itself

Abstract

The latent period of epileptogenesis represents a critical window for early diagnosis and preventive intervention before the disease progresses. Among epilepsy subtypes, posttraumatic epilepsy (PTE) and mesial temporal lobe epilepsy (mTLE) account for a significant proportion of cases. However, it remains unclear whether these two subtypes share common longitudinal network biomarkers during the latent phase. To address this question, we performed longitudinal functional and structural MRI in rat models of PTE induced by lateral fluid percussion injury (LFPI) and mTLE induced by intrahippocampal kainic acid (KA). The final dataset included 31 rats, comprising 18 KA/mTLE rats and 13 LFPI/PTE rats, with available MRI scans at pre-induction baseline, 1 week, and/or 8 weeks post-induction. We quantified lesion volume (LV), resting-state functional connectivity (rsFC), network topology, longitudinal changes, and rsFC-LV associations. In mTLE model, hippocampal rsFC increased at 1 week relative to baseline (p = 0.024) and declined globally at 8 weeks. Hippocampal rsFC was negatively associated with LV in the left hippocampus (week 1, p = 0.036), right hippocampus (week 8, p = 0.02), and sensorimotor cortex (week 8, p = 0.041). Network topology showed an early reduction followed by a later increase in clustering coefficient. In contrast, the PTE model displayed progressive rsFC reductions from baseline at both post-induction time points and higher clustering coefficient than mTLE. Despite overall rsFC declines in both models, mTLE retained greater prefrontal rsFC but lower hippocampal rsFC than PTE at 8 weeks. Etiology-specific LV differences were observed in hippocampus and sensorimotor cortex at week 8 (mTLE < PTE, p < 0.037). These findings demonstrate distinct, etiology-specific trajectories of rsFC, topology, and structure-function coupling in established rodent models of epileptogenesis.

Indexed as

Epilepsy, Post-TraumaticEpilepsy, Temporal LobeNerve NetAnimalsDisease Models, AnimalHippocampusKainic AcidLongitudinal StudiesMagnetic Resonance ImagingMaleNeural PathwaysRatsRats, Sprague-DawleyKainic AcidBrain lesionFunctional connectivityGeneral linear modelMesial temporal lobe epilepsyPosttraumatic epilepsyResting-state functional MRIStructural MRI

Identifiers

PMID42229742
PMCPMC13384022

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.