Evidence map›Paper›PMID 42229428›Full record

ArticleDevelopmental cell2026

Molecular cues from distinct neuron classes drive differential myelination in the neocortex.

Nuria Domínguez-Iturza, Vahbiz Jokhi, Kwanho Kim, Ashwin S Shetty, Daniela J Di Bella, Milagros Pereira Luppi, Wen Yuan, Catherine Abbate, Paul Oyler-Castrillo, Nalini A Oliver and 6 more

Abstract read
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In one paragraph

Article in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nuria Domínguez-IturzaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: nuriadomingueziturza@fas.harvard.edu.
Vahbiz JokhiDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Kwanho KimDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ashwin S ShettyDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Daniela J Di BellaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Milagros Pereira LuppiDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Wen YuanDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Catherine AbbateDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Paul Oyler-CastrilloDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Nalini A OliverDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vaishnavi VenkatDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Xin JinDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sean SimmonsStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Joshua Z LevinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Juliana R BrownDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Paola ArlottaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: paola_arlotta@harvard.edu.

Funding

Molecular principles of neuronal maturation and integration in the adult and aging brainR01NS103758 · NINDS · HARVARD UNIVERSITY · PI ARLOTTA, PAOLA, SCHINDER, ALEJANDRO FABIAN · 2018 to 2022
$2.7M
Neuron-Oligodendrocyte Communication Underlying Myelin Distribution in the NeocortexR01NS128117 · NINDS · HARVARD UNIVERSITY · PI Paola Arlotta · 2022 to 2026
$2.1M
NINDS NIH HHS R01 NS103758NINDS NIH HHS R01 NS128117
6 · The paper itself

Abstract

Oligodendrocytes deposit different amounts of myelin in each neocortical layer, but the regulatory process remains unclear. We present a single-cell map of oligodendrocyte lineage cells purified from different layers of the neocortex across developmental stages. We find that each layer contains a similar compendium of oligodendrocyte classes and differs primarily in the proportions of maturation states, suggesting that oligodendrocyte heterogeneity cannot explain layer-specific myelination. We show that signals from different classes of pyramidal neurons can control oligodendrocyte maturation and the differential distribution of myelin across cortical layers. We generated a ligand-receptor interactome to predict interactions between projection neuron types and oligodendrocyte states, across cortical layers and time, and validated candidates in vivo. We find that neuronal expression of Fgf18, Ncam1, and Rspo3 promotes cortical myelination. This work provides a comprehensive molecular description of oligodendrocyte development in the mouse cortex, pointing to mechanisms whereby neuron-class-linked signals modulate myelin distribution in the neocortex.

Indexed as

Myelin SheathNeocortexNeuronsOligodendrogliaAnimalsCell DifferentiationCell LineageGene Expression Regulation, DevelopmentalMiceNeurodevelopmentPyramidal CellsR-SpondinsThrombospondinsR-SpondinsThrombospondinscell-cell interactionscortical myelinationoligodendrocytesprojection neuronssingle-cell RNA sequencing

Identifiers

PMID42229428
PMCPMC13322639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.