Evidence map›Paper›PMID 42229425›Full record

ArticleCell reports. Medicine2026

Comprehensive mapping of human CD4

Alison Tarke, Mariah Macias, Claudia Francisco Morales, Tanner Michaelis, Leila Siddiqui, Esther Dawen Yu, Raphael Trevizani, Abril Zuniga, Christian Zmasek, Elizabeth Phillips and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alison TarkeCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Mariah MaciasCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Claudia Francisco MoralesCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Tanner MichaelisCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Leila SiddiquiCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Esther Dawen YuCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Raphael TrevizaniOswaldo Cruz Foundation, São José, S/N - Precabura, Eusébio, CE 61773-270, Brazil.
Abril ZunigaDepartment of Informatics, J. Craig Venter Institute, La Jolla, CA 92037, USA.
Christian ZmasekDepartment of Informatics, J. Craig Venter Institute, La Jolla, CA 92037, USA.
Elizabeth PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, WA WA 6150, Australia.
Simon MallalInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, WA WA 6150, Australia.
Brandon LinDepartment of Informatics, J. Craig Venter Institute, La Jolla, CA 92037, USA.
Jesus O EstevezDepartment of Informatics, J. Craig Venter Institute, La Jolla, CA 92037, USA.
Jonathan R ErlichDepartment of Informatics, J. Craig Venter Institute, La Jolla, CA 92037, USA.
Nicole V JohnsonDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Jason S McLellanDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
April FrazierCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Ricardo da Silva AntunesCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Gene S TanDepartment of Informatics, J. Craig Venter Institute, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Alba GrifoniCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Alessandro SetteCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA. Electronic address: alex@lji.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paramyxoviruses comprise a diverse family of viruses that threaten global human health through direct infection and zoonotic transmission. Understanding adaptive immune responses to these viruses is critical for characterizing host-pathogen interactions and evaluating vaccine performance. Here, we systematically map human CD4

Indexed as

CD4-Positive T-LymphocytesEpitope MappingEpitopes, T-LymphocyteMeaslesMeasles virusNipah VirusCross ReactionsHenipavirus InfectionsHumansEpitopes, T-LymphocyteCTERepitopesimmunogenic regionsmeaslesNipahpandemic preparednessParamyxovirussequence conservationT cellsvaccine

Identifiers

PMID42229425
PMCPMC13293922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.