Evidence map›Paper›PMID 42228961›Full record

ArticleJournal of neurophysiology2026

Long-distance object motion evokes direction selectivity in retinal neurons through nicotinic receptors in bipolar cells.

Jeremy M Bohl, Andrew M Garrett, Tomomi Ichinose

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeremy M BohlDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, United States.ORCID 0009-0009-0526-6258
Andrew M GarrettDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, United States.ORCID 0000-0001-5765-2585
Tomomi IchinoseDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, United States.ORCID 0000-0001-9233-9762

Funding

Mechanisms of Motion Detection in Retinal Neural NetworkR01EY028915 · NEI · WAYNE STATE UNIVERSITY · PI Tomomi Ichinose · 2018 to 2026
$3.8M
Mechanisms of Cell Adhesion Molecule Function in Retinal DevelopmentR01EY031690 · NEI · WAYNE STATE UNIVERSITY · PI GARRETT, ANDREW · 2021 to 2025
$1.9M
ON and OFF visual signaling in the retinal interneuronsR01EY032917 · NEI · WAYNE STATE UNIVERSITY · PI ICHINOSE, TOMOMI · 2021 to 2025
$1.9M
HHS | NIH | National Eye Institute (NEI) EY028915HHS | NIH | National Eye Institute (NEI) EY031690HHS | NIH | National Eye Institute (NEI) EY032917NEI NIH HHS R01 EY028915NEI NIH HHS R01 EY031690NEI NIH HHS R01 EY032917Wayne State University (WSU) Rumble Fellowship
6 · The paper itself

Abstract

In the retina, the direction of a moving object is encoded by starburst amacrine cells (SACs) and ON-OFF direction-selective ganglion cells (ooDSGCs). Multiple neural circuits have accounted for the underlying mechanisms of direction selectivity. We previously found that the cholinergic feedback circuit through α7-nicotinic acetylcholine receptors (α7-nAChRs) in bipolar cells mediates direction selectivity in SACs. We investigated whether distinct visual stimuli differently affected cholinergic feedback through α7-nAChRs. We conducted two-photon Ca

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorMotion PerceptionReceptors, NicotinicRetinal Bipolar CellsRetinal Ganglion CellsAnimalsFemaleMaleMiceMice, Inbred C57BLNicotinic Antagonistsalpha7 Nicotinic Acetylcholine ReceptorNicotinic AntagonistsReceptors, Nicotinicacetylcholinedirection selectivitynicotinic receptorsretina

Identifiers

PMID42228961
PMCPMC13287847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.