Evidence map›Paper›PMID 42228867›Full record

ArticleA&A practice2026

Probable Malignant Hyperthermia Presenting With Refractory Hypotension in a Young Trauma Patient: A Case Report.

Muhammad Y Azar, Jannah H Azar, Angela E Azar

Abstract readCase Reports
In one paragraph

Article in A&A practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Muhammad Y AzarFrom the Department of Anesthesiology, University of California Irvine Medical Center, Orange, California.
Jannah H AzarFrom the Department of Anesthesiology, University of California Irvine Medical Center, Orange, California.
Angela E AzarDepartment of Anesthesiology & Perioperative Care, University of California Irvine Medical Center, Orange, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant hyperthermia (MH) is a rare, life-threatening anesthetic complication caused by dysregulated skeletal muscle calcium homeostasis. We report a 25-year-old trauma patient who developed refractory hypotension with rising Etco2 despite progressive increases in minute ventilation, followed by hyperthermia, 2.5 hours after exposure to succinylcholine and sevoflurane. Hemodynamic instability was unresponsive to fluids and vasopressors but reversed rapidly after treatment for probable MH with dantrolene (Ryanodex). This case highlights early hemodynamic instability as a prominent manifestation of MH and emphasizes rising Etco2 despite increased ventilation as a critical diagnostic clue requiring prompt dantrolene administration.

Indexed as

HypotensionMalignant HyperthermiaAdultAnesthetics, InhalationDantroleneHumansMethyl EthersMuscle Relaxants, CentralSevofluraneSuccinylcholineAnesthetics, InhalationDantroleneMethyl EthersMuscle Relaxants, CentralSevofluraneSuccinylcholine

Identifiers

PMID42228867
PMCPMC13229204

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.