Evidence map›Paper›PMID 42228804›Full record

ReviewAging2026

The love and hate relationship between cellular senescence and stemness.

Angelos Papaspyropoulos, Giorgos Theocharous, Orestis A Ntintas, Konstantinos Evangelou, Vassilis G Gorgoulis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Angelos PapaspyropoulosMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Giorgos TheocharousMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Orestis A NtintasMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Konstantinos EvangelouMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Vassilis G GorgoulisMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence and stemness represent two biological entities with several opposing properties. However, both senescence and stemness serve to maintain tissue homeostasis, via different mechanisms. In adults, while non-dividing senescent cells represent a major barrier to potentially harmful cell insults, propagating stem cells are responsible for restoring the structure and functionality of damaged tissue. In this review, we highlight distinct cellular settings where an antagonistic relationship between the two states is naturally established. In contrast, major synergy between senescence and stemness is observed primarily in cancer, where inherent senescent cell features may actively promote the emergence of cancer stem cells. As the complex interplay between senescence and stemness may heavily vary between different cell types and physiological contexts, elucidating the nature of the interaction and the potential effects per case, is of considerable clinical importance.

Indexed as

AgingCellular SenescenceNeoplastic Stem CellsStem CellsAnimalsHumanssenescencestemness

Identifiers

PMID42228804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.