Evidence map›Paper›PMID 42228755›Full record

ArticlePloS one2026

A large language model framework for sample-free population synthesis.

Michael Jones, Richard Dawson, Jon Mills

Erratum issuedAbstract read
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Michael JonesSchool of Engineering, Newcastle University, Newcastle, United Kingdom.ORCID https://orcid.org/0009-0003-8249-4488
Richard DawsonSchool of Engineering, Newcastle University, Newcastle, United Kingdom.ORCID https://orcid.org/0000-0003-3158-5868
Jon MillsSchool of Engineering, Newcastle University, Newcastle, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic populations provide the demographic foundations for agent-based models in transport, public health, disaster management and other sectors, enabling credible representations of individual characteristics and behaviours. Many established synthesis methods rely on census microdata; however, such data are infrequently collected, privacy-restricted, and usually available only as small public-use samples at coarse geographic scales. This paper introduces a sample-free framework that uses a large language model (LLM) to generate complete, household-structured populations directly from aggregate demographic data. The framework is LLM agnostic and follows a multi-step process: objective definition, input preparation, LLM selection, and synthetic household generation. No model fine-tuning is required, meaning that data requirements are low and the framework is easily accessible. Population synthesis is formulated as an iterative prompting process in which an LLM generates households guided by the discrepancies between synthetic and target distributions. The model draws on prior knowledge encoded during pre-training to propose plausible attribute combinations, resulting in both statistical alignment and structural feasibility. In a global evaluation covering 109 countries, the framework achieved very close alignment on simpler marginals such as gender (SRMSE: 0.003) and household size (SRMSE: 0.026), while more structurally complex attributes such as household composition (SRMSE: 0.062) and age (SRMSE: 0.128) were also reproduced with good accuracy. These results were supported by detailed case studies in Newcastle upon Tyne (UK) and Dar es Salaam (Tanzania). The principal contribution of the framework is to enable the construction of coherent household-structured populations when detailed microdata are unavailable, expanding the applicability of agent-based modelling in data-constrained settings.

Indexed as

DemographyLarge Language ModelsFamily CharacteristicsHumans

Identifiers

PMID42228755
PMCPMC13229344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.