Evidence map›Paper›PMID 42228575›Full record

ArticleCell reports2026

NAT10-dependent N

Xujia Wu, Donghai Wang, Suchet Taori, Weichi Wu, Deobrat Dixit, Deguan Lv, Steven J Mullett, Stacy L Gelhaus, Fanen Yuan, Po Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xujia WuHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: wuxujia.sysu@gmail.com.
Donghai WangHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Suchet TaoriHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Weichi WuHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Deobrat DixitDepartment of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Deguan LvHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Steven J MullettDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.
Stacy L GelhausDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.
Fanen YuanHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Po ZhangHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Tengfei HuangHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Huairui YuanHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Qiulian WuHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Jeremy N RichHillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA. Electronic address: drjeremyrich@gmail.com.

Funding

Dynamic Complexity of Brain Tumor Stem Cells (R35CA197718)R35CA197718 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICH, JEREMY N · 2015 to 2021
$6.4M
Metabolic Regulation of Glioblastoma EpitranscriptomicsR01CA268634 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sameer Agnihotri, JEREMY N RICH · 2022 to 2026
$2.9M
Targeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)R01CA238662 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAY, STEVE A, RICH, JEREMY N · 2020 to 2024
$2.8M
Metabolic Control of Translation in GlioblastomaR01NS136424 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sameer Agnihotri, JEREMY N RICH · 2024 to 2026
$1.7M
Targeting Amino Acid Metabolism in GlioblastomaR01NS134724 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kalil G Abdullah, JEREMY N RICH · 2024 to 2026
$1.7M
Dual Targeting of Brain Tumor Initiating Cells through Inhibition of BMI1 and EZH2 (R01NS103434)R01NS103434 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICH, JEREMY N · 2017 to 2021
$1.7M
An Exploris 240 for MetabolomicsS10OD032141 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2022 to 2022
$600k
Bringing Untargeted Metabolomics to PittS10OD023402 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2018 to 2018
$594k
NCI NIH HHS R01 CA238662NCI NIH HHS R01 CA268634NCI NIH HHS R35 CA197718NIH HHS S10 OD023402NIH HHS S10 OD032141NINDS NIH HHS R01 NS103434NINDS NIH HHS R01 NS134724NINDS NIH HHS R01 NS136424
6 · The paper itself

Abstract

R-loop remodeling dynamically regulates chromatin states and gene expression; however, its exploitation by cancer to sustain self-renewal and malignancy remains poorly understood. Here, we find that glioblastoma (GBM) stem cells (GSCs) display highly active R-loops compared to differentiated progeny and neural stem cells. Genome-wide mapping reveals cell-specific enrichment and spatial accumulation of R-loops at promoter-proximal regions in GSCs, correlating with active transcription and open chromatin. We identify N-acetyltransferase 10 (NAT10) as a high-affinity R-loop-binding protein in GSCs, where it is overexpressed downstream of OLIG1. NAT10 catalyzes widespread N

Indexed as

CytidineGlioblastomaNeoplastic Stem CellsN-Terminal Acetyltransferase ER-Loop StructuresAnimalsBrain NeoplasmsCell Line, TumorCell ProliferationChromatinEarly Growth Response Protein 1Gene Expression Regulation, NeoplasticHumansMiceN-Terminal AcetyltransferasesPromoter Regions, GeneticChromatinCytidineEarly Growth Response Protein 1N-acetylcytidineNAT10 protein, humanN-Terminal Acetyltransferase EN-Terminal Acetyltransferasesac(4)Ccancer stem cellCP: cancerCP: neuroscienceEGR1epitranscriptomicsglioblastomaglioblastoma stem cellNAT10R-loop remodelin

Identifiers

PMID42228575
PMCPMC13589288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.