Evidence map›Paper›PMID 42228567›Full record

ArticleCell reports2026

Conserved role of primary motor cortex in the control of prehension in mice and macaques.

Francisco Aparicio, Harman Ghuman, Preeya Khanna, Sapeeda Barati, Robert Morecraft, Christoph Kirst, Karunesh Ganguly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francisco AparicioDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; San Francisco VA Medical Center, San Francisco, CA 94158, USA.
Harman GhumanDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; San Francisco VA Medical Center, San Francisco, CA 94158, USA.
Preeya KhannaDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Sapeeda BaratiDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; San Francisco VA Medical Center, San Francisco, CA 94158, USA.
Robert MorecraftLaboratory of Neurological Sciences, Division of Biomedical and Translational Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA.
Christoph KirstDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: christoph.kirst@ucsf.edu.
Karunesh GangulyDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; San Francisco VA Medical Center, San Francisco, CA 94158, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA. Electronic address: karunesh.ganguly@ucsf.edu.

Funding

Optimizing oscillatory epidural electrical stimulation to selectively increase task-related population dynamics in motor areasR01NS117406 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANGULY, KARUNESH, MORRISON, JOHN H · 2020 to 2024
$3.4M
Modulating Low-Frequency Cortical Population Dynamics to Augment Motor Function After StrokeR01NS112424 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANGULY, KARUNESH, MORECRAFT, ROBERT J · 2020 to 2024
$3.2M
Long-term reliable neuroprosthetic control of a robotic arm and hand using electrocorticography.R01HD111562 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Edward Chang, Karunesh Ganguly · 2024 to 2026
$2.0M
Untangling the influence of distinct sources of somatosensory feedback on the neural dynamics of dexterous movement controlDP2NS142717 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KHANNA, PREEYA · 2024 to 2024
$1.3M
Neural dynamics of somatosensory guidance of dexterous movement in intact and stroke-injured networksK99NS124748 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHANNA, PREEYA · 2021 to 2022
$222k
NICHD NIH HHS R01 HD111562NINDS NIH HHS DP2 NS142717NINDS NIH HHS K99 NS124748NINDS NIH HHS R01 NS112424NINDS NIH HHS R01 NS117406RRD VA I01 RX001640
6 · The paper itself

Abstract

A central goal in neuroscience is to develop cross-species frameworks that reveal conserved principles of movement control. Recent work has suggested a potential species difference in the role of primary motor cortex (M1) during skilled forelimb tasks: in rodents, extensive practice appears to shift control to subcortical circuits, leading to "disengagement" of M1 from task execution. Importantly, there is no evidence of such disengagement in macaques. We hypothesized that these differences instead reflect task demands, particularly the need for fine (i.e., grasping) versus gross motor control. Strikingly, M1 lesions in macaques produced recovery patterns similar to rodents: gross motor control, including an exclusively gross motor task, recovered rapidly, whereas fine motor control exhibited persistent deficits. Detailed kinematic analyses in both macaques and mice performing a single-pellet reach-to-grasp task (RGT) revealed analogous disruptions in the temporal structure of sub-movements. These findings underscore the importance of task design and the translational value of rodent models for understanding motor control and recovery.

Indexed as

Hand StrengthMotor CortexAnimalsBiomechanical PhenomenaFemaleForelimbMaleMiceMotor SkillsCP: neurosciencedexteritygraspinglesionmotor cortexprehensionreachingrecovery

Identifiers

PMID42228567
PMCPMC13379984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.