Evidence map›Paper›PMID 42228531›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.

Richard G Webster, Setareh Alabaf, Anna Li, Rene Beerli, Sandra Siehler, Pierre-Eloi Imbert, Leonard Lee, Judith Cossins, Magdalena Koziczak-Holbro, Ludivine Flotte and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Richard G WebsterNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DS, United Kingdom.ORCID 0000-0001-7893-1348
Setareh AlabafNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DS, United Kingdom.
Anna LiNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DS, United Kingdom.
Rene BeerliNovartis Biomedical Research, Basel CH-4056, Switzerland.ORCID 0009-0005-4709-9524
Sandra SiehlerNovartis Biomedical Research, Basel CH-4056, Switzerland.
Pierre-Eloi ImbertNovartis Biomedical Research, Basel CH-4056, Switzerland.
Leonard LeeNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DS, United Kingdom.ORCID 0000-0002-9562-3723
Judith CossinsNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DS, United Kingdom.
Magdalena Koziczak-HolbroNovartis Biomedical Research, Basel CH-4056, Switzerland.
Ludivine FlotteNovartis Biomedical Research, Basel CH-4056, Switzerland.ORCID 0009-0002-3471-1073
Laurent GaudetNovartis Biomedical Research, Basel CH-4056, Switzerland.
Nicole GerwinNovartis Biomedical Research, Basel CH-4056, Switzerland.
David BeesonNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DS, United Kingdom.ORCID 0000-0001-9395-7132
Yin Y DongNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DS, United Kingdom.ORCID 0000-0001-8600-6988

Funding

UKRI | Medical Research Council (MRC) MR/M006824UKRI | Medical Research Council (MRC) MR/S007180/1
6 · The paper itself

Abstract

The muscle nicotinic acetylcholine receptor (AChR) is the key mediator of neuromuscular signal transmission and is essential for all voluntary movement in our body. In this study, we present DC-98-LC74, a positive allosteric modulator (PAM) for the adult skeletal muscle-type AChR. Through using Ca

Indexed as

Allosteric RegulationReceptors, NicotinicAnimalsDiaphragmHEK293 CellsHumansMaleMiceMice, Inbred C57BLMuscle, SkeletalReceptors, Nicotinicacetylcholine receptorallosteric modulatormyastheniasarcopenia

Identifiers

PMID42228531
PMCPMC13250566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.