ArticleAlzheimer disease and associated disorders
Early Gut Microbiome Alterations in Mild Cognitive Impairment Reflect Changes in Alzheimer Disease.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlterations in the gut-brain axis have been increasingly linked to neurodegenerative diseases, including Alzheimer disease (AD). It remains unclear whether these microbiome changes are already present during early cognitive decline. We examined whether gut microbiome alterations characteristic of AD are detectable in mild cognitive impairment (MCI) and whether these changes follow a similar pattern across the cognitive continuum.
methodsThis case-control study included 78 participants: 37 cognitively healthy controls, 20 individuals with MCI, and 21 individuals with prodromal or mild AD. Cognitive performance was assessed using the CERAD neuropsychological battery, and disease severity was assessed using the Clinical Dementia Rating. Dietary data were collected, and fecal samples were analyzed using 16S rRNA gene amplicon sequencing.
resultsWe identified 16 bacterial genera associated with cognitive status. Genera such as Lacticaseibacillus , Raoultella , and Buttiauxella were reduced in AD, with similar decreases already evident in MCI. In contrast, Anaerovorax and an unclassified Comamonadaceae genus were increased in AD. Several alterations showed a consistent trend from normal cognition through MCI to AD. DISCUSSION: Gut microbiome alterations characteristic of AD appear already present in early cognitive decline and follow a similar pattern in MCI. These findings support the potential of microbiome profiles as early, noninvasive biomarkers of AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.