Evidence map›Paper›PMID 42228269›Full record

ArticleMolecular and cellular biochemistry2026

The role of mitochondrial regulation in macrophage polarization by Ganoderma lucidum polysaccharide for the treatment of colitis-associated colorectal cancer.

Zhaorong Ouyang, Wanqiu Ye, Guolei Wen, Siyu Li, Tao Wei, Maowen Chen, Biao Cai, Houli Liu

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhaorong OuyangCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Wanqiu YeCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Guolei WenCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Siyu LiCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Tao WeiCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Maowen ChenCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Biao CaiCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China. caibiao@ahtcm.edu.cn.
Houli LiuCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China. houliliu0706@ahtcm.edu.cn.

Funding

Anhui University of Chinese Medicine 2023AH050755National Natural Science Foundation of China 82305041
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Ganoderma lucidum polysaccharide (GLP) has shown significant potential in regulating macrophage polarization and treating CRC. However, the role of mitochondrial regulation in GLP-mediated macrophage polarization in azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated CRC remains unclear. Therefore, we performed cellular and animal experiments to explore how GLP influences mitochondrial dynamics and function, macrophage polarization, and exerts its therapeutic effect against AOM/DSS-induced colitis-associated CRC. The results showed that Mdivi-1 attenuated GLP-induced changes in mitochondrial dynamics and function, further reduced the M1/M2 macrophage ratio. In vivo experiments confirmed that GLP modulates mitochondrial function, promotes M1 macrophage polarization, and thereby inhibits CRC progression without significant side effects. This study provides new insights into the role of mitochondrial modulation in GLP-mediated macrophage polarization and suggests a potential therapeutic avenue for colitis-associated CRC treatment.

Indexed as

ColitisColitis-Associated NeoplasmsColorectal NeoplasmsFungal PolysaccharidesMacrophagesMitochondriaPolysaccharidesReishiAnimalsDextran SulfateHumansMaleMiceMice, Inbred C57BLDextran SulfateFungal PolysaccharidesPolysaccharidesColorectal cancerGanoderma lucidum polysaccharideMacrophage polarizationMitochondrial regulation

Identifiers

PMID42228269

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.