Evidence map›Paper›PMID 42228202›Full record

ReviewAnnals of hematology2026

AML with t(16;21)(p11.2;q22)/FUS::ERG rearrangement presenting with hemophagocytes and multinucleated cells: a case report and literature review.

Yingying Chen, XinhongYang, Zhihua Zhang, Xiaofeng Yang

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yingying ChenDepartment of Hematology, the Affiliated Hospital of Chengde Medical University Chengde, Chengde, Hebei Province, China.
XinhongYangDepartment of Hematology, the Affiliated Hospital of Chengde Medical University Chengde, Chengde, Hebei Province, China. 18503149286@163.com.
Zhihua ZhangDepartment of Pediatric Surgery, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province, China.
Xiaofeng YangHebei Key Laboratory of Panvascular Diseases, Chengde, China.

Funding

Chengde Science and Technology Plan Project 202303A058
6 · The paper itself

Abstract

The FUS::ERG fusion gene is rare in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), with a predominant prevalence in individuals of Asian descent. The incidence of AML harboring the FUS::ERG fusion gene is approximately 1%.Including the present case, a total of 154 cases have been reported in the literature to date.CSF3R mutation is rare in AML and frequently coexist with other genetic abnormalities to drive leukemogenesis.In this article,A case of AML harboring t(16;21)(p11.2;q22)/FUS::ERG and CSF3R mutations was retrospectively analyzed, with frequent identification of hemophagocytes and multinucleated cells in the bone marrow, and the relevant literature was reviewed.

Indexed as

Chromosomes, Human, Pair 16Chromosomes, Human, Pair 21Gene RearrangementLeukemia, Myeloid, AcuteOncogene Proteins, FusionRNA-Binding Protein FUSTranslocation, GeneticHumansMaleFUS protein, humanOncogene Proteins, FusionRNA-Binding Protein FUSTLS-ERG fusion protein, humanAcute myeloid leukemiaFUS::ERG fusion geneHemophagocytesMultinucleated cells

Identifiers

PMID42228202
PMCPMC13427884

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.