ArticleSleep & breathing = Schlaf & Atmung2026
STOP-BANG-Defined high OSA risk is associated with left ventricular diastolic dysfunction in obese adults.
Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundObesity is strongly associated with left ventricular diastolic dysfunction (LVDD), an early phenotype along the heart failure with preserved ejection fraction spectrum. Obstructive sleep apnea (OSA) is common in obesity and may coexist with epicardial adiposity, systemic inflammation, and autonomic imbalance; however, whether screening-defined high OSA risk is associated with LVDD in obese adults remains uncertain.
objectiveTo evaluate associations of OSA risk, epicardial adipose tissue (EAT) thickness, systemic inflammatory indices, and heart rate variability (HRV) with LVDD in obese adults and to explore their screening-oriented discriminative performance.
methodsIn this single-center, cross-sectional study, consecutive adult patients presenting to the cardiology outpatient clinic between January and December 2025 were screened. Eligible participants were adults in sinus rhythm with adequate echocardiographic image quality. The final cohort included 279 participants: 113 obese adults (body mass index [BMI] ≥ 30 kg/m
resultsLVDD was more frequent in obese participants than in non-obese controls (43% vs 7%, p < 0.001). Within the obese subgroup, high STOP-BANG risk (≥ 3) was associated with greater EAT thickness, higher inflammatory burden, and lower HRV indices. In multivariable analyses restricted to obese participants, high STOP-BANG risk remained associated with LVDD in both the full model (OR 2.67, 95% CI 1.25-5.71; p = 0.011) and the reduced model (OR 2.55, 95% CI 1.31-5.55; p = 0.011). A reduced screening-oriented model incorporating STOP-BANG category, EAT thickness, and inflammatory indices showed acceptable discrimination for LVDD in obese adults.
conclusionsIn obese adults, STOP-BANG-defined high OSA risk is associated with a phenotype characterized by greater epicardial adiposity, higher inflammatory burden, autonomic impairment, and a higher prevalence of LVDD. A parsimonious model integrating STOP-BANG, EAT thickness, and inflammatory indices may support screening-oriented phenotypic characterization of obese adults with a higher likelihood of LVDD; however, these findings should not be interpreted as establishing causal inference or diagnostic confirmation of OSA.
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