Evidence map›Paper›PMID 42228177›Full record

SynthesisArchives of gynecology and obstetrics2026

The incremental yield of CMA over karyotype in fetal ventriculomegaly: a systematic review and meta-analysis.

Ioakeim Sapantzoglou, Zacharias Fasoulakis, Konstantinos Tasias, Angeliki Rouvali, Afroditi Pegkou, Marianna Theodora, Georgios Daskalakis, Panagiotis Antsaklis

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ioakeim Sapantzoglou1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece. ioakeimsap@med.uoa.gr.
Zacharias Fasoulakis1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece.
Konstantinos Tasias1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece.
Angeliki Rouvali1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece.
Afroditi Pegkou1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece.
Marianna Theodora1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece.
Georgios Daskalakis1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece.
Panagiotis Antsaklis1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe main objective of our study was to conduct a systematic literature review and a meta-analysis to evaluate the incremental yield of chromosomal microarray analysis compared to karyotyping in cases of fetal ventriculomegaly.

methodsOur review was designed according to the PRISMA guidelines. It included all observational studies that reported the results of CMA testing in fetuses diagnosed with ventriculomegaly (both isolated and non-isolated),in fetuses with isolated ventriculomegaly, in fetuses with non-isolated ventriculomegaly, and in fetuses with mild isolated ventriculomegaly.

results16 studies were included with a total of 2137 cases of affected fetuses that met the inclusion criteria for analysis. Combined data from these studies revealed an overall incremental yield of CMA over karyotyping of 7% (95% CI 4-10%) in cases with ventriculomegaly, 4% (95% CI 2-6%) in isolated cases, 10% (95% CI 6-16%) in non-isolated cases, and 2% (95% CI 1-4%) in mild isolated cases.

conclusionsOur findings may be useful in clinical practice to guide management options and the counseling of the couples to individualize patient care and facilitate clinicians when they come across such a common clinical entity.

Indexed as

HydrocephalusKaryotypingMicroarray AnalysisPrenatal DiagnosisFemaleHumansKaryotypePregnancyArray CGHCMAFetal ventriculomegalyKaryotypeVM

Identifiers

PMID42228177
PMCPMC13442320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.