Evidence map›Paper›PMID 42228111›Full record

Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

The use of centrifugated autologous lipoaspirate in the endoscopic management of idiopathic subglottic stenosis: results from a retrospective non-randomized study.

Francesco Mattioli, Margherita Basso, Antonio Moretti, Greta Morselli, Caterina Vaccari, Edoardo Serafini, Cinzia Del Giovane, Massimo Pinelli, Daniele Marchioni, Alessandro Marchioni

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comment on "The use of centrifugated autologous lipoaspirate in the endoscopic management of idiopathic subglottic stenosis: results from a retrospective non-randomized study".European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Francesco MattioliDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Modena, Largo del Pozzo, 71, Modena, 41124 , Italy.ORCID http://orcid.org/0000-0002-1481-668X
Margherita BassoDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Modena, Largo del Pozzo, 71, Modena, 41124 , Italy. margherita.basso410@gmail.com.ORCID http://orcid.org/0000-0002-0457-6299
Antonio MorettiRespiratory Diseases Unit and Center for Rare Lung Disease, Department of Surgical and Medical Sciences, University Hospital of Modena, Modena, Italy.ORCID http://orcid.org/0000-0002-4386-746X
Greta MorselliDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Modena, Largo del Pozzo, 71, Modena, 41124 , Italy.ORCID http://orcid.org/0009-0009-1207-7164
Caterina VaccariDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital Sant'Orsola of Bologna, Bologna, Italy.
Edoardo SerafiniDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital Sant'Orsola of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-4519-1299
Cinzia Del GiovaneUnit of Statistical and Methodological Support to Clinical Research, University Hospital of Modena, Modena, Italy.ORCID http://orcid.org/0000-0002-5028-932X
Massimo PinelliDepartment of Medical and Surgical Sciences, Division of Plastic Surgery, University of Modena and Reggio Emilia, Policlinico of Modena, Modena, Italy.
Daniele MarchioniDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Modena, Largo del Pozzo, 71, Modena, 41124 , Italy.ORCID http://orcid.org/0000-0002-8004-7284
Alessandro MarchioniRespiratory Diseases Unit and Center for Rare Lung Disease, Department of Surgical and Medical Sciences, University Hospital of Modena, Modena, Italy.ORCID http://orcid.org/0000-0003-3720-3517

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIdiopathic subglottic stenosis (iSGS) is a rare, progressive fibroinflammatory disease that predominantly affects middle-aged women. Although endoscopic treatments have improved, recurrence rates remain high and no standardized therapeutic approach has been defined. This exploratory retrospective pilot study aimed to assess feasibility, safety and explore the preliminary signal of benefit of intralesional injection of centrifuged autologous lipoaspirate as an adjunct to endoscopic balloon dilation in patients with iSGS.

methodsA retrospective pilot observational study was conducted at the Tracheal Team of the University Hospital of M. and the Otorhinolaryngology Unit of S.O. Hospital, B., I., from 2015 to 2024. Twenty-six adult women with histologically confirmed iSGS and at least 12 months of follow-up were included. Patients received either standard endoscopic balloon dilation with intralesional corticosteroid injection (n=19) or balloon dilation followed by injection of centrifuged autologous lipoaspirate (n=7). The primary outcome was recurrence within 24 months, defined as the need for reintervention due to symptomatic restenosis. Secondary outcomes included time-to-recurrence, Subglottic Stenosis-6 (SGS-6) scores, and perioperative complications.

resultsOverall, recurrence occurred in 16 of 26 patients (61.6%). Recurrence was lower in the lipoaspirate group (2/7, 28.6%) compared with the standard group (14/19, 73.7%), with Pearson's χ² of 4.4 (P = 0.036; Fisher's exact P=0.06). Median time-to-recurrence was longer in the lipoaspirate group (482 days) than in the standard group (240 days) (Long-rank test p=0.047).

conclusionsIn this retrospective pilot study, patients with idiopathic subglottic stenosis treated with intralesional injection of centrifuged autologous lipoaspirate following endoscopic balloon dilation showed a preliminary signal of lower recurrence rate and longer recurrence-free survival.

Indexed as

LaryngoscopyLaryngostenosisAdultAgedFemaleHumansInjections, IntralesionalMiddle AgedPilot ProjectsRecurrenceRetrospective StudiesTreatment OutcomeAutologous lipoaspirate injectionIdiopatic subglottic stenosisLaryngotracheal stenosisRegenerative medicine

Identifiers

PMID42228111
PMCPMC13388530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.