ReviewDer Nervenarzt2026
[Neuropsychiatric manifestations of sex chromosome aberrations-Clinical and therapeutic aspects of neuropsychiatric care].
Review in Der Nervenarzt, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
backgroundSex chromosome aberrations affect approximately 1.5 per 1000 individuals, although somatically inconspicuous phenotypes can remain undetected. Even when diagnosed, the elevated risk of neuropsychiatric manifestations needs to be specifically addressed in psychiatric care.
methodsThis narrative review analyzes the current literature on neuropsychiatric manifestations of sex chromosome syndromes, focusing on the four most common forms (Klinefelter, Turner, XYY and triple‑X syndromes).
resultsSex chromosome aberrations show characteristic neuropsychiatric manifestations. Frequent psychiatric manifestations include attention deficit hyperactivity disorder, autism spectrum disorders, anxiety disorders, affective and psychotic disorders. Cognitive impairments affect the majority of individuals and are manifested in speech developmental disorders, executive dysfunctions or visuospatial deficits. Severe intellectual impairments are rare (< 5-10%).
conclusionHeightened clinical attention to neuropsychiatric manifestations of sex chromosome aberrations facilitates earlier diagnosis and access to developmental, psycho(pharmaco)logical and endocrinological treatment approaches to improve the quality of life and social participation of those affected.
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