Evidence map›Paper›PMID 42227972›Full record

ArticleeLife2026

Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein.

Zhongying Han, Sabrina Panhans, Sophie Brameyer, Ecenaz Bilgen, Marija Ram, Anna Herr, Alessandra Narducci, Michael Isselstein, Paul David Harris, Oliver Brix and 8 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Conformational Dynamics of Plasmepsin X during Inhibitor Binding.The journal of physical chemistry. B · 2026
    Article
  4. Undirected Exploration of Binding Pockets with Flexible Topology.Journal of chemical theory and computation · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zhongying HanPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Sabrina PanhansPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Sophie BrameyerMicrobiology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Ecenaz BilgenDepartment of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID https://orcid.org/0000-0003-4919-5104
Marija RamPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Anna HerrPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Alessandra NarducciPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Michael IsselsteinPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Paul David HarrisDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Faculty of Mathematics & Science, The Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, Israel.
Oliver BrixPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Pazit ConPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Kirsten JungMicrobiology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Don C LambDepartment of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID https://orcid.org/0000-0002-0232-1903
Eitan LernerDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Faculty of Mathematics & Science, The Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-3791-5277
Douglas GriffithPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Thomas R WeiklDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.ORCID https://orcid.org/0000-0002-0911-5328
Niels ZijlstraPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.
Thorben CordesPhysical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID https://orcid.org/0000-0002-8598-5499

Funding

Structural dynamics of RNAP-promoter complex in late transcription initiationR01GM130942 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, SHIMON · 2019 to 2022
$2.2M
Alexander von Humboldt Foundation Postdoctoral fellowshipBundesministerium für Forschung, Technologie und Raumfahrt quantumFRETChinese Scholarship Council PhD scholarshipDeutsche Forschungsgemeinschaft 449926427Deutsche Forschungsgemeinschaft CO 879/4-1Deutsche Forschungsgemeinschaft GRK2062Deutsche Forschungsgemeinschaft SFB1035Deutsche Forschungsgemeinschaft SFB863European Commission 10.3030/638536Israel Science Foundation 3565/20Israel Science Foundation 556/22NIGMS NIH HHS R01 GM130942Zuckerman STEM 2022-2023 Postdoctoral fellowship
6 · The paper itself

Abstract

The glutamine-binding protein GlnBP is part of an ATP-binding cassette transporter system in

Indexed as

Escherichia coliEscherichia coli ProteinsGlutaminePII Nitrogen Regulatory ProteinsCalorimetryCarrier ProteinsKineticsLigandsMolecular Dynamics SimulationProtein BindingProtein ConformationSurface Plasmon ResonanceCarrier ProteinsEscherichia coli ProteinsGlutamineglutamine transport proteinsLigandsPII Nitrogen Regulatory ProteinsE. colifluorescenceFRETligand binding mechanismmolecular biophysicsproteinssingle-molecule detectionstructural biology

Identifiers

PMID42227972
PMCPMC13229503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.