ArticleJACC. Case reports2026
Dilated and Noncompaction Cardiomyopathy in a Pediatric Patient With Maternal CASZ1 Variant.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe CASZ1 gene expresses a cardiomyocyte transcription factor implicated in early heart morphogenesis. CASZ1 variants have been associated with the development of dilated cardiomyopathy (DCM) and noncompaction cardiomyopathy (NCCM), although reported cases are limited. CASE SUMMARY: A 3-month-old boy with no family history of cardiomyopathy presented with a murmur and persistent tachycardia. Echocardiogram showed moderate global left ventricular hypokinesis with trabeculations and mild left atrial dilation. Genetic testing identified an autosomal dominant CASZ1 variant in exon 15, c.3088del:p.(His1030Thrfs∗120), inherited from his asymptomatic mother. Although he is clinically doing well at age 18 months, he will need lifelong management. DISCUSSION: Our case highlights the discovery of a novel CASZ1 variant leading to DCM and NCCM, emphasizing the importance of genetic testing in patients with no known family history. TAKE-HOME MESSAGE: Genetic testing is a critical component of the workup of unexplained DCM and NCCM in pediatric patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.