Evidence map›Paper›PMID 42227811›Full record

ArticleJournal of virology2026

Clonal expansion and phenotypic alterations of TCR Vβ3

Shilan Li, Wei Wang, Yun Peng, Guixiang Wang, Yue Xi, Shengcai Wang, Jing Zhao, Fengzhen Zhang, Hua Wang, Hongbin Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shilan Li *Department of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Wei Wang *Laboratory of Tumor Immunology, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-1257-3079
Yun Peng *Laboratory of Tumor Immunology, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Guixiang WangDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yue XiDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Shengcai WangDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Jing ZhaoDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Fengzhen ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Hua WangDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Hongbin LiDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Qingchuan DuanDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Ting LongDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Jingang GuiLaboratory of Tumor Immunology, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-3431-8749
Xin NiDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-7781-2600
Jie ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-1621-7779

Funding

National Natural Science Foundation of China 81970867National Natural Science Foundation of China 82101204Respiratory Research Project of National Clinical Research Center for Respiratory Diseases HXZX-20210201
6 · The paper itself

Abstract

Juvenile-onset recurrent respiratory papillomatosis (JORRP) is a rare, human papillomavirus (HPV)-driven pediatric disease characterized by recurring papillomas in the respiratory tract. The contribution of dysregulated T-cell immunity to disease severity remains poorly understood. This study included 97 JORRP patients and 124 controls. Due to sample limitations, downstream analyses, including flow cytometry, TCR, and RNA sequencing, were performed on distinct patient subsets (detailed in Methods). We identified a selective expansion of TCR Vβ3

Indexed as

ChemokinesPapillomavirus InfectionsReceptors, Antigen, T-Cell, alpha-betaRespiratory Tract InfectionsT-LymphocytesCell MovementChildFemaleHuman Papillomavirus VirusesHumansMaleSignal TransductionTumor MicroenvironmentChemokinesReceptors, Antigen, T-Cell, alpha-betachemokine signalingclonal expansionHPVJORRPTCR Vβtumor microenvironment

Identifiers

PMID42227811
PMCPMC13288611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.