Evidence map›Paper›PMID 42227762›Full record

ArticlemSystems2026

Multi-cohort comparative analysis of salivary microbiotas reveals rural Ethiopians harbor a distinct composition correlated with lower esophageal cancer prevalence.

Girma Mulisa, Jingcheng Zhao, Geda Lelissa, Iyunoluwa J Ademola-Popoola, Anastacia Marie Diaz Huemme, Laura S Weyrich, Adane Mihret, Tufa Gemechu, Abate Bane, Roger Pero-Gascon and 4 more

Abstract readComparative Study
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Girma MulisaDepartment of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-3619-8579
Jingcheng ZhaoDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0004-0447-6652
Geda LelissaDepartment of Internal Medicine, St Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Iyunoluwa J Ademola-PopoolaDepartment of Anthropology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0008-9050-9914
Anastacia Marie Diaz HuemmeDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0003-3388-4885
Laura S WeyrichDepartment of Anthropology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0001-5243-4634
Adane MihretDepartment of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia.
Tufa GemechuDepartment of Pathology, School of Medicine College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Abate BaneDepartment of Internal Medicine, School of Medicine College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Roger Pero-GasconCenter of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.ORCID 0000-0001-5019-1405
Marthe De BoevreCenter of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.ORCID 0000-0002-6151-5126
Sarah De SaegerCenter of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.ORCID 0000-0002-2160-7253
Tamrat Abebe *Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia.
Jordan E Bisanz *Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-8649-1706

Funding

Decoding Microbial Diversity in the Human Gut MicrobiomeR35GM151045 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Jordan Adam Bisanz · 2023 to 2026
$1.5M
European Research Council 946192 HUMYCONational Science Foundation DGE1255832NIGMS NIH HHS R35 GM151045Research Foundation Flanders 12D4423N
6 · The paper itself

Abstract

Esophageal cancer (EC) results in high mortality due to difficulty in early diagnosis, particularly in low- and middle-income countries, including the African EC belt typified by high prevalence, early onset, and poor prognosis. While the precise etiological factors remain unknown, emerging data suggest links to the oral microbiota. In this study, we conducted a secondary analysis using V4 16S rRNA sequencing from a cross-sectional study of treatment-naive, newly diagnosed EC patients (

Indexed as

Esophageal NeoplasmsMicrobiotaSalivaAdenocarcinomaAdultAgedCohort StudiesCross-Sectional StudiesEast African PeopleEsophageal Squamous Cell CarcinomaEthiopiaFemaleHumansMaleMiddle AgedPrevalenceRNA, Ribosomal, 16Sesophageal cancermeta-analysismicrobiomesaliva

Identifiers

PMID42227762
PMCPMC13288984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.