Evidence map›Paper›PMID 42227699›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2026

Placental discrepancies between Black and White patients with preeclampsia in a southeastern US cohort.

Madison Ives, Gibson Cooper, Cayman Bickerstaff, Mona Elgazzaz, Cassandra Sam, Amalia Brawley, Safia Ogbi, Elisabeth Mellott, Desmond Moronge, Stephanie Stokes and 6 more

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Madison IvesDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.ORCID 0009-0008-4166-1821
Gibson CooperDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Cayman BickerstaffDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.ORCID 0009-0004-8828-0488
Mona ElgazzazDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Cassandra SamDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Amalia BrawleyDepartment of OBGYN, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.ORCID 0000-0002-1416-1003
Safia OgbiDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Elisabeth MellottDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.ORCID 0000-0003-3692-5905
Desmond MorongeDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.ORCID 0000-0001-8134-0645
Stephanie StokesDepartment of OBGYN, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Joanna HitchingsDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Luis Valesquez ZarateDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Sravankumar KavuriDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Padmashree C WoodhamDepartment of OBGYN, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.ORCID 0000-0001-6942-2074
James MaherDepartment of OBGYN, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Jessica L FaulknerDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.ORCID 0000-0003-3362-412X

Funding

Regulation and role of leptin in preeclampsiaR01HL169576 · NHLBI · AUGUSTA UNIVERSITY · PI Jessica L. Faulkner · 2023 to 2026
$2.1M
A novel role for endothelial mineralocorticoid receptors in obesity-associated cardiovascular disease in femalesR00HL146948 · NHLBI · AUGUSTA UNIVERSITY · PI FAULKNER, JESSICA L. · 2021 to 2023
$747k
American Heart Association (AHA) 25SFRNPCKMS1469680American Heart Association (AHA) AHA1192508American Heart Association (AHA) AHA 1196923American Heart Association (AHA) AHA 1362572HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R00HL146948HHS | NIH | NHLBI | Division of Intramural Research (DIR) R01HL169576NHLBI NIH HHS R00 HL146948NHLBI NIH HHS R01 HL169576
6 · The paper itself

Abstract

Preeclampsia is a devastating hypertensive disorder of pregnancy with a high prevalence in the southern regions of the United States. Black pregnant patients are disproportionally at higher risk for preeclampsia onset and severity of disease than other racial groups. The underlying mechanism(s) for this racial disparity are unclear. In our current study, we were able to obtain a cohort of patients of self-identifying Black or White race who were overall matched for body mass index (BMI), blood pressure, gestational and maternal age, and parity, and we hypothesized that placentas from Black patients with preeclampsia would demonstrate elevated preeclampsia-associated placental gene expressions compared with White patients with preeclampsia. We collected placenta tissue from both healthy individuals and preeclampsia Black and White patients (

Indexed as

Black or African AmericanPlacentaPre-EclampsiaWhiteAdultCase-Control StudiesCohort StudiesEndothelin-Converting EnzymesFemaleHumansLeptinPregnancySoutheastern United StatesYoung AdultECE1 protein, humanEndothelin-Converting EnzymesLeptinendothelinleptinplacentapreeclampsiaracial discrepancies

Identifiers

PMID42227699
PMCPMC13366324

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.