Evidence map›Paper›PMID 42227661›Full record

ArticleJournal of immunology research2026

Associations Between Immune Senescence and Immune Reconstitution Among People Living With HIV Undergoing Antiretroviral Therapy.

Zhe Qian, Huolan Long, Houji Wu, Jingfang Xie, Suling Chen, Jian Wu, Shaohang Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhe QianSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Southern Medical University, Guangzhou, China, fimmu.com.ORCID https://orcid.org/0000-0001-7762-4186
Huolan LongSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Southern Medical University, Guangzhou, China, fimmu.com.
Houji WuDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China, fimmu.com.
Jingfang XieDepartment of Geriatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, China, gdghospital.org.cn.
Suling ChenDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China, fimmu.com.
Jian WuSecond Department of Elderly Respiratory, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Southern Medical University, Guangzhou, China, fimmu.com.ORCID https://orcid.org/0000-0003-0008-899X
Shaohang CaiDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China, fimmu.com.ORCID https://orcid.org/0000-0003-3765-9127

Funding

Guangzhou Science and Technology Program key projects 2025A04J4146National Natural Science Foundation of China 82500570Natural Science Foundation of Guangdong Province 2026A1515010711
6 · The paper itself

Abstract

backgroundFailure of immune reconstitution (IR), characterized by suboptimal CD4

objectiveThis study aimed to determine the role of pre-ART immune senescence characterized by lymphocyte profile and lymphocyte cellular senescence markers in nonimmune reconstitution (NIR) after 48 weeks of ART initiation.

methodsWe first performed a SenMayo gene set score from publicly available CD4

resultsBioinformatics analysis revealed multiple ART-naïve CD4

conclusionPre-ART immune senescence is strongly associated with NIR in PLWHIV receiving ART. These findings necessitate considering immunological age and immune senescent status for personalized therapeutic strategies.

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsImmune ReconstitutionImmunosenescenceAdultAntiretroviral Therapy, Highly ActiveBiomarkersCD4 Lymphocyte CountCellular SenescenceCytokinesFemaleHumansImmunophenotypingMaleMiddle AgedBiomarkersCytokinesAIDSHIVimmune reconstitutionimmune senescence

Identifiers

PMID42227661
PMCPMC13239133

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.