Evidence map›Paper›PMID 42227659›Full record

ArticleACS infectious diseases2026

Cytochrome P450-Mediated Metabolism of Antimycobacterial

Johannes Doering, Erik Meerz, Rüdiger W Seidel, Markus Lang, Andreas M Kany, Seppo Auriola, Risto Olavi Juvonen, Hannu Raunio, Richard Goddard, Matthew D Zimmerman and 4 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Johannes DoeringInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.
Erik MeerzInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.
Rüdiger W SeidelInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.ORCID 0000-0003-3438-4666
Markus LangInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.
Andreas M KanyHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.
Seppo AuriolaSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Box 1627, Kuopio FI-70211, Finland.
Risto Olavi JuvonenSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Box 1627, Kuopio FI-70211, Finland.ORCID 0000-0001-9240-7673
Hannu RaunioSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Box 1627, Kuopio FI-70211, Finland.
Richard GoddardMax-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.ORCID 0000-0003-0357-3173
Matthew D ZimmermanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110,United States.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110,United States.ORCID 0000-0001-9470-5009
Anna K H HirschHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.ORCID 0000-0001-8734-4663
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110,United States.ORCID 0000-0002-9604-9452
Adrian RichterInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.ORCID 0000-0002-0062-7896

Funding

Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
NIAID NIH HHS R01 AI132374
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AmidesAnti-Bacterial AgentsCytochrome P-450 Enzyme SystemPhenylalanineAnimalsChromatography, LiquidMycobacterium tuberculosisOxidation-ReductionTandem Mass SpectrometryAmidesAnti-Bacterial AgentsCytochrome P-450 Enzyme SystemPhenylalanine

Identifiers

PMID42227659
PMCPMC13270519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.