Evidence map›Paper›PMID 42227643›Full record

ArticleMediators of inflammation2026

Urinary Polycyclic Aromatic Hydrocarbons and Advanced Cardiovascular-Kidney-Metabolic Syndrome: Inflammatory-Nutritional Pathways as Mediators.

Yifeng Huang, Youxia Zhao, Qizhang Man, Song Liu, Ying Yang, Jinfeng Wen, Lei Fan, Hao Xie, Keyun Zhang, Jing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yifeng HuangNephrology Department of Ganzhou People's Hospital, Ganzhou, Jiangxi, China, gzsrmyy.com.ORCID https://orcid.org/0009-0004-6734-6492
Youxia ZhaoDepartment of Medical Imaging Center, Nan Fang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou, 510515, Guangdong, China, fimmu.com.ORCID https://orcid.org/0009-0006-7627-224X
Qizhang ManSchool of Stomatology, Southern Medical University, Guangzhou, 510515, Guangdong, China, fimmu.com.ORCID https://orcid.org/0009-0002-0450-5201
Song LiuThe First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China, fimmu.com.ORCID https://orcid.org/0009-0000-0018-2826
Ying YangThe First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China, fimmu.com.ORCID https://orcid.org/0009-0003-6026-0226
Jinfeng WenSchool of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, Guangdong, China, fimmu.com.ORCID https://orcid.org/0009-0001-2526-4091
Lei FanDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China, fimmu.com.
Hao XieDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China, fimmu.com.ORCID https://orcid.org/0009-0003-8562-6757
Keyun ZhangDepartment of Joint Sport Medicine, The Fist Affiliated Hospital of Hunan Medical College, 225 Yushi Road, Huaihua, 418000, Hunan, China.ORCID https://orcid.org/0000-0002-6256-3496
Jing WangNephrology Department of Ganzhou People's Hospital, Ganzhou, Jiangxi, China, gzsrmyy.com.ORCID https://orcid.org/0009-0001-3397-7710

Funding

China Postdoctoral Science Foundation 2024T170380Guangzhou Science and Technology Planning Project 2023A04J2314National Natural Science Foundation of China Youth Fund 82202662Natural Science Foundation of Guangdong Province 2024A1515012767
6 · The paper itself

Abstract

backgroundPolycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants linked to adverse health outcomes. Their role in the different statuses of Cardiovascular-Kidney-Metabolic (CKM) syndrome remains poorly understood.

methodsA cross-sectional analysis of 11,043 participants was conducted using data from NHANES. Urinary PAH levels were measured, and advanced CKM status was assessed using established diagnostic criteria. Mediation analysis was performed to evaluate the role of the red blood cell distribution width-to-albumin ratio (RAR).

resultsHigher urinary levels of PAHs, particularly 2-NAP and 2-FLU, were significantly associated with advanced CKM syndrome (p < 0.05). Exposure-response relationships and threshold effects were observed for these key PAHs. Mediation analysis identified RAR as a novel biomarker, explaining 6.13%-37.81% of the association depending on the specific metabolite.

conclusionsThis study reveals that PAHs are independently and jointly associated with advanced CKM status, with RAR serving as a critical mediator. These findings underscore the importance of reducing environmental PAH exposure and highlight RAR as a potential biomarker for early detection and risk stratification.

Indexed as

Cardiovascular DiseasesMetabolic SyndromePolycyclic Aromatic HydrocarbonsAdultBiomarkersCross-Sectional StudiesEnvironmental ExposureEnvironmental PollutantsFemaleHumansInflammationMaleMiddle AgedNutrition SurveysBiomarkersEnvironmental PollutantsPolycyclic Aromatic HydrocarbonsCKM syndromeenvironmental exposuremediation analysispolycyclic aromatic hydrocarbonsred blood cell distribution width-to-albumin ratio

Identifiers

PMID42227643
PMCPMC13239313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.