Evidence map›Paper›PMID 42227580›Full record

ArticleBioconjugate chemistry2026

Enhancing Triggered Release of Polar Cargo from ROS-Responsive Liposomes.

Annaleena Hansen, Mayesha B Mustafa, Jinchao Lou, Michael D Best

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Annaleena HansenDepartment of Chemistry; University of Tennessee Knoxville, 1420 Circle Drive, Knoxville, Tennessee 37996, United States.
Mayesha B MustafaDepartment of Chemistry; University of Tennessee Knoxville, 1420 Circle Drive, Knoxville, Tennessee 37996, United States.
Jinchao LouDepartment of Chemistry and Biochemistry, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0001-5064-761X
Michael D BestDepartment of Chemistry; University of Tennessee Knoxville, 1420 Circle Drive, Knoxville, Tennessee 37996, United States.ORCID 0000-0001-8737-5910

Funding

Liposome Targeting and Triggered Release Driven by Reactive Oxygen SpeciesR15GM146193 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI BEST, MICHAEL D. · 2022 to 2022
$459k
NIGMS NIH HHS R15 GM146193
6 · The paper itself

Abstract

Liposomes are promising nanocarriers because of their ability to encapsulate and deliver therapeutic cargo with wide-ranging physicochemical properties. However, liposome delivery could be improved by enhancing triggered release of cargo and particularly doing so in a manner that is selective toward diseased cells. Reactive oxygen species (ROS) provide exciting targets to explore as triggers for the development of stimuli-responsive liposomes due to substantial differences in ROS abundance between diseased versus healthy cells. While our group previously reported ROS-responsive liposomes using a synthetic lipid switch, polar cargo release was slow and limited using our original platform. Herein, we report an improved ROS-responsive lipid switch (

Indexed as

LiposomesReactive Oxygen SpeciesBoronic AcidsFluorescent DyesHydrogen PeroxideHydrophobic and Hydrophilic InteractionsBoronic AcidsFluorescent DyesHydrogen PeroxideLiposomesReactive Oxygen Species

Identifiers

PMID42227580
PMCPMC13432994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.