Evidence map›Paper›PMID 42227522›Full record

ArticleCurrent medicinal chemistry2026

Apoptosis, Pyroptosis, and Necroptosis (PANoptosis) may be Present in Renal Ischemic Injury.

Lewen Wang, Shuang Lu, Dongsheng Zhao, Guoqian Hu, Guijiang Tang, Kun Xiong, Jin Tang, Weitao Yan

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Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lewen WangDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
Shuang LuDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
Dongsheng ZhaoDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
Guoqian HuDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
Guijiang TangDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
Kun XiongDepartment of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Jin TangDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
Weitao YanDepartment of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEmerging evidence suggests that a novel inflammatory programmed cell death pathway, PANoptosis-entailing the co-activation of apoptosis, pyroptosis, and necroptosis-may contribute to renal ischemic injury. While growing research implicates PANoptosis in the pathogenesis of diverse ischemic conditions, its specific role in AKI has not been thoroughly elucidated.

methodsTo test whether PANoptosis exists in renal ischemia diseases, we screened renal ischemia injury involving apoptosis, pyroptosis, and necroptosis as the research model and analyzed the data. Meanwhile, we detected the expression of several marker proteins (cleaved caspase-3, p-MLKL, NLRP3, and GSDMD) in HK-2 cells following ischemic injury.

resultsThe bibliometric results indicate that there is a large number of studies on apoptosis, pyroptosis, and necroptosis in cell and animal models simulating renal ischemia- reperfusion injury. Meanwhile, the experimental results show that in the ischemia- reperfusion injury model of HK-2 cells, the expression levels of key molecules involved in apoptosis, pyroptosis, and necroptosis change. DISCUSSION: Our results demonstrate the involvement of PANoptosis in renal ischemic injury, offering a basis for targeted therapies against renal ischemia-related diseases and supporting the development of PANoptosis inhibitors.

conclusionCollectively, our findings indicate that a PANoptosis-like cell death process occurs in renal ischemic injury.

Indexed as

ApoptosisIschemiaKidneyNecroptosisPyroptosisReperfusion InjuryAnimalsCell LineHumansapoptosisischemia/reperfusionnecroptosisPANoptosisPANoptosomepyroptosisregulated cell deathrenal

Identifiers

PMID42227522

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.