ArticleCurrent medical imaging2026
Early Differentiation of Prostatic Intraepithelial Neoplasia via Multiparametric MRI Combined with PSA-derived Parameters
Article in Current medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProstatic intraepithelial neoplasia (PIN) is a precancerous lesion. Early differentiation of PIN is very important for the prevention of PIN occurrence and malignization.
objectivesTo differentiate prostatic intraepithelial neoplasia (PIN) via multiparametric MRI (mpMRI) combined with prostate-specific antigen (PSA)-derived parameters. MATERIALS AND
methodsFrom March 2022 to June 2024, 47 males, including 39 with benign prostatic hyperplasia (BPH) and 8 with PIN, were enrolled. All patients underwent prostatic mpMRI. The apparent diffusion coefficients (ADC), Ktrans, kep, ve, initial area under curve (iAUC), and PI-RADS score were derived from mpMRI. The parameters between PIN and BPH were compared via Student's t test or Mann-Whitney U test. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy.
resultsThe ADC value of PIN was significantly greater than that of BPH (0.912 vs. 0.806 × 10-3 mm2/s, P=0.035). The tPSA, fPSA, and PSA density (PSAD) of PIN were significantly lower than those of BPH (6.715 vs. 11.640 ng/mL, P=0.008; 1.427 vs. 2.109 ng/mL, P=0.042; 0.095 vs. 0.158 ng/mL2, P=0.010; respectively). The AUC of tPSA was slightly greater than those of PSAD, ADC, and fPSA (0.801 > 0.792 > 0.724 > 0.716) in differentiating PIN from BPH. When the tPSA was ≤ 8.47 ng/mL, the highest sensitivity (87.5%) and negative predictive value (96.8%) were observed in differentiating PIN from BPH. When the ADC and PSA-derived parameters were combined, the highest specificity (94.9%) was acquired in differentiating PIN from BPH. ADC (OR=0.120, P = 0.043) and PSAD (OR=0.056, P = 0.005) were independent risk predictors for differentiating PIN from BPH. DISCUSSION: ADC derived from mpMRI combined with PSA-derived parameters exhibit enormous potential for differentiating PIN from BPH.
conclusionsADC and PSA-derived parameters can distinguish PIN from BPH. The ADC value combined with tPSA can achieve the highest diagnostic efficiency in detecting PIN. The ADC may function as a potential biomarker to differentiate precancerous lesions of the prostate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.