Evidence map›Paper›PMID 42227379›Full record

ReviewEndocrine, metabolic & immune disorders drug targets2026

Microbiome and its Association with Diseases of the Ear, Nose and Pharynx.

Siti Nur Syakinah Md Sabudin, Srijit Das, Norsyamira Aida Mohamad Umbaik, Siti Rosmani Md Zin

Abstract readReview
In one paragraph

Review in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Siti Nur Syakinah Md SabudinMedical and Basic Dental Sciences Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0003-0553-7248
Srijit DasDepartment of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.ORCID 0000-0001-8302-7257
Norsyamira Aida Mohamad UmbaikDepartment of Otorhinolaryngology- Head and Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0003-4556-7601
Siti Rosmani Md ZinMedical and Basic Dental Sciences Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0002-4114-8664

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe microbiome refers to the entire community of microorganisms, including bacteria, fungi, viruses, their genes, and the environment that surrounds them. The microbiome is found in the gut, skin, and the oral and nasal cavities, and is an important interface between the human body and the environment outside. Notably, the ear, nose, and throat or pharynx microbiome remains poorly studied. Therefore, the present review discusses the association of the microbiome with various diseases of the ear, nose, and pharynx.

methodsThe literature was obtained by conducting a comprehensive search of the PubMed, Scopus, Web of Science, and Google Scholar databases, followed by screening the abstracts for relevance. The selected articles were then retrieved for deeper exploration.

resultsThis review highlights the disturbance of the balance of the microbiome, which is referred to as dysbiosis, that may be the cause of various diseases in the body. DISCUSSION: We also discuss various microorganisms found in the ear, nose, and pharynx and their link with related diseases and brain health.

conclusionThe microbiome is important for the better health of the human body as it modulates the immune system. Accordingly, a better understanding of its interaction with the host may lead to advances in drug design.

Indexed as

Ear DiseasesMicrobiotaNose DiseasesPharyngeal DiseasesPharynxAnimalsDysbiosisHumansdrug deliverydysbiosisENT diseasesMicrobiomemicroorganismspharynx

Identifiers

PMID42227379
PMCPMC13670191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.