Evidence map›Paper›PMID 42227333›Full record

ReviewNucleic acids research2026

A ligase-based toolbox for research and diagnostics in molecular medicine.

Ulf Landegren

Abstract readReview
In one paragraph

Review in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ulf LandegrenMolecular Tools, Department of Immunology, Genetics & Pathology, Science for Life Laboratory, Uppsala University, Se-75185, Uppsala, Sweden.ORCID 0000-0002-7820-1000

Funding

European Research CouncilNovo Nordisk FoundationSwedish Cancer FoundationSwedish Research CouncilSwedish Strategic FoundationUS National Cancer Institute
6 · The paper itself

Abstract

New approaches for molecular analysis continuously open new vistas in molecular medicine. Our lab has built a series of molecular detection techniques based on enzymatic ligation of synthetic oligonucleotides as versatile tools to gain new molecular insights. These fundamental techniques continue to yield new means for specific, high-throughput analyses of nucleic acids and proteins in contexts of relevance for molecular medicine. The combined potential for vast multiplexing and low sample consumption renders the assays described herein attractive as a basis for AI-assisted model building in medicine. Accordingly, this overview is aimed to present a ligase-based molecular toolbox to choose from in addressing present and upcoming analytical needs.

Indexed as

LigasesMolecular MedicineHumansOligonucleotidesLigasesOligonucleotides

Identifiers

PMID42227333
PMCPMC13227105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.