ArticleArchives of Razi Institute2025
Multi-epitope HA Vaccine Confers Cross-protective Immunity to H5N8 and H9N2.
Article in Archives of Razi Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Introduction: Avian influenza viruses, notably H5N8 (HPAI) and H9N2 (LPAI), threaten public health due to their zoonotic potential and genetic adaptability. These viruses circulate in poultry and can sometimes directly infect humans after contact with infected birds. Some existing vaccines have proven useful in controlling these infections. Traditional vaccines targeting the variable hemagglutinin (HA) head domains necessitate frequent updates. This study designs a chimeric HA (cHA H9/H5) vaccine targeting conserved epitopes from H5N8 and H9N2 HA proteins to elicit broad immunity. Materials & Methods: A multi-epitope construct, integrating B-cell and cytotoxic T lymphocyte (CTL) epitopes linked via stabilizing sequences (KK, AAY, GPGPG), was codon-optimized, expressed in Results: The cHA H9/H5 vaccine induced robust HI titers against homologous H9N2 (log Conclusion: These results highlight the cHA H9/H5 vaccine's ability to overcome strain-specific limitations by targeting conserved epitopes, inducing cross-reactive immunity that is critical for pandemic preparedness. Adjuvant selection proved pivotal in optimizing responses, aligning with prior chimeric HA vaccine research. This study advances the development of universal influenza vaccines, offering a promising strategy to mitigate risks posed by evolving avian influenza variants.
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