ArticleArchives of Razi Institute2025
Protective Effects of
Article in Archives of Razi Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Acrylamide (AA) is a chemical compound that poses a major public health concern. This study aimed to evaluate the protective effect of Materials & Methods: Thirty male albino rats weighing 150-200 g were equally and randomly divided into some groups: Control group received normal saline vehicle daily via oral gavage for 30 days, AA group received 15 mg/kg body weight of AA dissolved in 0.2 mL saline solution daily via oral gavage for 30 days. NS group received 15 mg/kg body weight (bw) of AA combined with 1 mL/kg bw of NS oil daily via oral gavage for 30 days. At the end of the experiment, rats were euthanized, and SMGs were dissected for histological evaluation, including hematoxylin and eosin staining (H&E) and immunohistochemistry for inducible nitric oxide synthase (iNOS), as well as analysis for heme oxygenase-1 ( Results: The acinar and ductal cells of SMG of the AA group showed signs of degeneration and toxicity in the form of ill-defined outlines, pyknotic and crescent-shaped nuclei with different-sized cytoplasmic vacuolations. These changes were statistically significant with increased iNOS immunoexpression and Conclusion: NS effectively mitigated these toxic effects, suggesting its potential as a natural antioxidant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.