ArticleClinical medicine insights. Endocrinology and diabetes2026
The Relationship Between the Polymorphisms of RANK Gene and Type 2 Diabetes Mellitus in Postmenopausal Women.
Article in Clinical medicine insights. Endocrinology and diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Studies have indicated an association between the receptor activator of nuclear factor-κB (RANK) gene and the pathogenesis of type 2 diabetes mellitus (T2DM). This study aimed to investigate the relationship between the polymorphisms at the RANK gene loci (rs3018362 and rs78326403) and T2DM in postmenopausal women from Xinjiang, China. Methods: This study enrolled 200 postmenopausal Han Chinese women who attended the First Affiliated Hospital of Shihezi University from October 2024 to March 2025. The research subjects were divided into two groups based on their medical history and results of the oral glucose tolerance test (OGTT): normal glucose tolerance group (NGT group, Results: 1) After correction for multiple testing using the Benjamini-Hochberg method, the levels of FPG, HbA Conclusion: The polymorphism at the rs3018362 locus of the RANK gene may be related to T2DM in postmenopausal women from Xinjiang, China. Additionally, the polymorphism at the rs78326403 locus may be involved in glucose and lipid metabolism.
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