ArticleCureus2026
Comprehensive Morphological and Immunohistochemical Evaluation of Gastrointestinal Stromal Tumors: Insights From a Tertiary Care Center.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal neoplasms of the gastrointestinal tract, typically originating from the interstitial cells of Cajal. Accurate histopathological assessment and immunohistochemical profiling are pivotal for diagnosis and risk stratification. This study aimed to evaluate the clinicopathological characteristics and immunohistochemical expression patterns of GISTs diagnosed at a tertiary care center. Methods A retrospective analysis was conducted on 30 histologically confirmed cases of GIST over a seven-year period. Formalin-fixed, paraffin-embedded tissue samples were reviewed using hematoxylin and eosin staining and subjected to immunohistochemistry. Parameters assessed included patient demographics, tumor location, histological subtype, mitotic index, and immunoreactivity for CD117, DOG1, and CD34. Results The cohort comprised 19 men and 11 women, with a mean age of 62.1 years. The small intestine had the most number of cases, i.e., eight cases (26%), followed by the stomach, which had seven cases (24%). Spindle cell morphology was predominant (86%), followed by epithelioid and mixed patterns (7% each). Most tumors were low-grade (60%), with a mitotic rate of <5 per 50 high-power fields. Immunohistochemically, DOG1 showed the highest positivity (97%), followed by CD117 (84%) and CD34 (70%). Smooth muscle actin (SMA), desmin, and S-100 showed variable positivity. Conclusion This study highlights a male predominance and a predilection for gastric and small intestinal involvement in GISTs. Spindle cell morphology and low mitotic activity were common histological features. Immunohistochemistry remains indispensable for diagnosis, with DOG1 demonstrating superior sensitivity. These findings reinforce the critical role of integrated histopathological and immunohistochemical evaluation in the accurate diagnosis and management of GISTs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.