Evidence map›Paper›PMID 42226810›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Absence of significant hematologic abnormalities in breastfed infants of mothers with multiple sclerosis treated with anti-CD20 therapies.

Anna Shah, Enrique Alvarez

Abstract read
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Enrique AlvarezRocky Mountain MS Center, Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID https://orcid.org/0000-0001-5854-9643

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To assess hematologic abnormalities in breastfed infants of mothers with multiple sclerosis (MS) receiving anti-CD20 therapies. Methods: Breastfed infants with maternal anti-CD20 use were identified. Infant blood draws examined B-cell (CD19) and hematological counts. Results: Nine of 10 identified infants had CD19 percentages in ranges expected for age. One infant had CD19 levels below the 5 Discussion: The absence of significant CD19 abnormalities in our cohort may indicate infant hematology safety. This may allow mothers MS to utilize anti-CD20 therapies while breastfeeding.

Indexed as

B-cellbreastfeedingbreastmilkkesimptalactatingmultiple sclerosisocrelizumabocrevusofatumumabRituxanrituximab

Identifiers

PMID42226810
PMCPMC13222397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.