ArticleDrug design, development and therapy2026
Anlotinib Plus Immune Checkpoint Inhibitors versus Chemotherapy in Elderly Patients with Extensive-Stage Small-Cell Lung Cancer: A Real World, Exploratory Study.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This retrospective study aimed to compare the real-world effectiveness and safety of anlotinib plus immune checkpoint inhibitors (ICIs) combination therapy versus chemotherapy in elderly patients with extensive-stage small-cell lung cancer (ES-SCLC). Methods: A total of 119 elderly patients (age ≥65 years) with ES-SCLC were screened and included in this study. Patients who received anlotinib plus ICIs (N = 59) were treated as observation group (OG). Subjects who received single-agent chemotherapy (irinotecan, docetaxel or paclitaxel) (N = 60) were deemed as control group (CG). Overall survival (OS) was the primary endpoint. Secondary endpoints included progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), Duration of response (DoR) and tolerability. Kaplan-Meier methods and Log rank tests were used to analyze OS/PFS/DoR with Cox proportional hazards modeling for multivariate analysis. Results: Median age was comparable with 71 years in both groups. Anlotinib plus ICIs showed significantly prolonged survival: median OS was 11.9 months (95% CI: 8.93-14.87) in OG versus 6.7 months (95% CI: 3.41-9.99) in CG (HR=0.53, 95% CI: 0.35-0.81, Conclusion: Anlotinib combined with ICIs demonstrated improved OS compared to single-agent chemotherapy with acceptable safety profile in elderly patients with ES-SCLC. These real-world findings were hypothesis-generating and required confirmation in prospective trials.
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