ArticleEuropean heart journal. Imaging methods and practice2026
Myocardial deformation links combined liraglutide-empagliflozin therapy with improved cardiovascular and economic outcomes in type 2 diabetes: a 6-year study.
Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03878706 (The Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination on Endothelial Function, Arterial Stiffness and Left Ventricular Deformation in Patients With Type 2 Diabetes With High Cardiovascular Risk), which is not on this map. Not yet cited in PubMed.
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The Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination on Endothelial Function, Arterial Stiffness and Left Ventricular Deformation in Patients With Type 2 Diabetes With High Cardiovascular Risk
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10 authors.
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Abstract
Aims: We investigated whether the early favourable effects of combined GLP-1 receptor agonist (GLP-1RA) and SGLT2 inhibitor (SGLT2i) therapy in left ventricular deformation is associated with long-term cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM). We also addressed the healthcare costs. Methods and results: We enrolled 336 consecutive participants with T2DM, aged 60 ± 10 years old, 252/336 (75%) were males and were categorized into four groups: insulin, liraglutide, empagliflozin, and liraglutide+ empagliflozin. We measured at baseline and at 6 months left ventricular global longitudinal strain (LVGLS) via echocardiography. Patients were followed for 6 years and we recorded the incidence of composite endpoint of non-fatal cardiovascular events (myocardial infarction, heart failure hospitalization, ischaemic stroke, and coronary revascularization). Multivariable Cox regression models were built to assess associations between treatment groups, LVGLS changes, and outcomes. A cost analysis was also conducted. At 6 months LVGLS increased significantly ( Conclusion: Combined GLP-1RA and SGLT2i therapy is associated with early improvement in myocardial deformation, which translates into reduced long-term cardiovascular risk and favourable economic outcomes. ClinicalTrials.gov Identifier: NCT03878706.
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