Trial reportLasers in surgery and medicine2026
Evaluating the Use of High-Intensity Non-Focused Ultrasound Treatment to Improve Skin Laxity and Facial Wrinkles in Asian Patients.
Trial report in Lasers in surgery and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
objectivesThis study aims to investigate the safety and efficacy of high-intensity, non-focused, parallel ultrasound treatments to lift lax tissue in the submental and neck zones, lift the eyebrow, and improve facial wrinkles in an Asian population.
methodsThis prospective, open-label, non-randomized single-center, self-controlled clinical study recruited 42 participants aged 35 to 67. Participants received a single treatment, covering the full face, neck, and submental zones. Standardized images were taken, and assessments were performed using the Physician Global Aesthetic Improvement Scale (PGAIS) and Fitzpatrick Classification of Wrinkling and Degree of Elastosis. 3D images were taken to calculate the volume change after treatment.
resultsAmong the 42 patients, 83.3% showed improvement in submental and neck skin laxity at the 3-month follow-up. Improvements were also observed in eyebrow elevation (28.6%) and facial wrinkles (38.1%) at 3 months. The Fitzpatrick Wrinkle and Elastosis Scale showed improvement in 26.2% of patients at 3 months, with sustained effects up to 9 months in 12.8% of patients. A trend of volumetric reduction of 1.04 ± 3.49 ml (p = 0.06) was demonstrated in the jawline and submental area. Transient edema and erythema were noted in 7.2% and 50% of patents initially but resolved on subsequent follow-up visits, and no other adverse events were documented.
conclusionsHigh-intensity, non-focused, parallel ultrasound is effective in improving skin laxity and facial wrinkles in Asian patients, with minimal side effects and good tolerability.
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