ArticleAnimal bioscience2026
The mechanisms of lncBMP4 mediating BMP4 promoter activity to regulate the proliferation of dermal papilla cells in Hu sheep.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveDermal papilla cells (DPCs) are the regulatory center of hair follicle (HF) development, and their proliferation is critical in HF growth studies. Long non-coding RNAs (lncRNAs) have been demonstrated to regulate the HF growth cycle. This study aims to elucidate the molecular mechanisms by which lncRNA regulates HF formation.
methodsBased on previous RNA sequencing results, this study identified differentially expressed lncRNA-lncBMP4 in Hu sheep skin tissues with distinct patterns. The lncBMP4 was characterized by using nuclear-cytoplasmic localization and fluorescence in situ hybridization. Its effect on DPCs proliferation was validated using reverse transcription quantitative polymerase chain reaction, CCK-8, and EdU assays. Subsequently, we further investigated the regulatory role of lncBMP4 on BMP4 using a Dual Luciferase Assay and an RNA immunoprecipitation experiment.
resultsThis study found that lncBMP4 is primarily localized in the cell nucleus and can inhibit the proliferation of Hu sheep DPCs. It acts by modulating the BMP4 promoter activity, which influences BMP4 expression and, consequently, the proliferation of Hu sheep DPCs.
conclusionThe current study elucidates the role and molecular mechanism of lncBMP4 in the pattern development of Hu sheep.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.