Trial reportBMC oral health2026
Clinical evaluation of cold plasma surface activation using different plasma systems on early implant stability: a randomized controlled within-patient trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07348770 (Clinical Evaluation of Cold Plasma Surface Activation Using Different Plasma Systems on Early Implant Stability), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Evaluation of Cold Plasma Surface Activation Using Different Plasma Systems on Early Implant Stability: A Randomized Controlled Within-Patient Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly implant stability is a relevant surrogate during the transition from mechanical primary stability to biologically mediated secondary stability. Cold plasma activation may improve titanium surface readiness, but direct clinical comparisons remain limited.
methodsThis prospective, single-center, randomized, within-patient controlled trial compared untreated control implants with three pre-insertion plasma protocols: vacuum plasma, argon jet plasma, and cold atmospheric plasma. Eleven patients received 44 implants. One patient/four implants was excluded for insufficient primary stability. The final analysis included 40 implants in 10 patients, each contributing one implant per group. Implant sites were not anatomically mirrored. Plasma was applied for 60 s before placement. Implant stability quotient (ISQ) was recorded at baseline and at 14, 28, and 56 days. A nested linear mixed-effects model was used for statistical inference.
resultsAll analyzed implants remained in situ throughout follow-up, and no adverse events were recorded. Baseline ISQ values were comparable across groups (70.6-70.9), without establishing anatomical equivalence. Control implants showed a transient ISQ decrease at day 28, whereas plasma-treated implants showed increasing ISQ values. The group-by-time interaction was significant (likelihood-ratio chi-square(9) = 188.73, p < 0.001). At day 56, model-based mean differences versus control were + 10.0 ISQ units for vacuum plasma, + 8.9 for argon jet plasma, and + 8.3 for cold atmospheric plasma (all p < 0.001). Sensitivity analyses preserved the association direction.
conclusionsCold plasma activation was associated with a more favorable early ISQ trajectory than untreated implants during the first 8 weeks. Given the small, retrospectively registered, site-heterogeneous, ISQ-based design, larger prospectively registered, site-standardized trials are warranted.
trial registrationRetrospectively registered at ClinicalTrials.gov, NCT07348770. First submitted: 11 December 2025; first posted: 16 January 2026; latest update posted: 11 May 2026.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.