ArticleVirology journal2026
Isolation and characterization of a novel lytic phage Artin targeting typhoidal and nontyphoidal Salmonella and evaluation of its antibacterial efficacy in food.
Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundPhages are increasingly viewed as powerful natural tools for controlling Salmonella and other foodborne pathogens, offering an alternative to conventional antimicrobials. However, the extensive serotype diversity of Salmonella and the rise of phage-resistant strains highlight the need for isolating phages with broader host ranges and strictly lytic activity. Advancing such phage resources is essential for developing reliable biocontrol strategies.
methodsIn this study, a novel lytic phage with significant potential to combat various Salmonella strains was isolated from dog feces. Morphological and biological characteristics of phage Artin were assessed using transmission electron microscopy, stability assays under different temperature and pH conditions, and adsorption assays. Structural proteins were analyzed by SDS-PAGE. The host range was determined against four Salmonella serovars and six non-Salmonella species. Whole-genome sequencing followed by bioinformatics analysis was performed to elucidate the genomic features of Artin. The ability of phage Artin to control Salmonella Enteritidis in chicken breast meat and milk was further assessed at 4 °C. Statistical analysis was carried out using GraphPad Prism 8.0.
resultsGenomic analysis classified Salmonella_phage_Artin within the Caudoviricetes class, Markadamsvirinae subfamily, and Epseptimavirus genus, with a dsDNA genome size of 118,477 bp and a GC content of 39.78%, featuring 192 coding sequences (CDS) devoid of antimicrobial resistance, virulence factors, and toxins. Phage Artin showed strong stability over a wide range of temperatures (4-70 °C) and pH levels (2-12). Approximately 53% of phage particles adsorb to host cells within 5 min. In addition to S. Enteritidis, phage Artin was also able to infect S. Typhimurium, S. Typhi, S. Choleraesuis, and Escherichia coli. At 4 °C, Artin reduced recoverable Salmonella in chicken breast by 1.3 log
conclusionsPhage Artin is a strictly lytic phage with broad host range and high stability, effectively reducing S. Enteritidis in chicken and milk, highlighting its potential as a safe and efficient biocontrol agent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.