Evidence map›Paper›PMID 42226115›Full record

ArticleBMC genomics2026

Whole-genome resequencing revealed genetic diversity and the haplotype containing MC1R associated with black coat color in Liangshan sheep.

Xueliang Sun, Jiazhong Guo, Jiahan Li, Jing Luo, Yiming Gong, Guo Wu, Mancheng Zhang, Feng Xu, Yuan Xu, Chengqi Wei and 4 more

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Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Xueliang Sun *Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Jiazhong Guo *Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Jiahan LiKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Jing LuoKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Yiming GongKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Guo WuKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Mancheng ZhangKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Feng XuAnimal Genetics and Breeding Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, No.7, Niusha Road, Chengdu, 610066, China.
Yuan XuAnimal Genetics and Breeding Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, No.7, Niusha Road, Chengdu, 610066, China.
Chengqi WeiAnimal Genetics and Breeding Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, No.7, Niusha Road, Chengdu, 610066, China.
Li LiKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.
Ran LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Quzhe EmuAnimal Genetics and Breeding Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, No.7, Niusha Road, Chengdu, 610066, China. arthuremu@163.com.
Hongping ZhangKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China. zhp@sicau.edu.cn.

Funding

CARS CARS-39-30Liangshan Prefecture Science and Technology Plan Project 24YZGG0006Sichuan Science and Technology Program 2021YFYZ0003Sichuan Science and Technology Program 2023YFN0082
6 · The paper itself

Abstract

backgroundCoat color was an economic trait in sheep, and identifying the causal variations affecting its diverse phenotypes had long been of interest. We performed whole-genome sequencing (WGS) to investigate the genetic composition and conducted a genome-wide association study (GWAS) for coat color using our lab data for 115 sheep (80 newly sequenced) from four Liangshan populations. Additionally, we retrieved public data for 104 sheep (from six other breeds) and 44 wild sheep.

resultsOur study revealed that the Liangshan sheep population exhibited moderate genetic diversity and a closer genetic relationship with Yunnan sheep. Using WGS data, we performed a GWAS to identify genetic loci and causal variants influencing the black coat pigmentation in 115 Liangshan sheep (i.e., 85 white coat LSS vs. 30 black coat LSB). GWAS identified a 1.526 Mb region (including the MC1R gene) on CHI14, spanning from 12,982,495 bp to 14,508,891 bp, as significantly associated with black coat (- log

conclusionsThis study clarified the population structure of Liangshan sheep and confirmed the MC1R c.361G > A mutation as a key locus influencing the black coat of LSB, potentially acting via the H2 haplotype.

Indexed as

Genetic VariationHair ColorHaplotypesPigmentationReceptor, Melanocortin, Type 1Whole Genome SequencingAnimalsGenome-Wide Association StudyPhenotypePolymorphism, Single NucleotideSheepReceptor, Melanocortin, Type 1Coat colorGenome-wide association studyMC1RPopulation structureSheepWhole-genome sequencing

Identifiers

PMID42226115
PMCPMC13439785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.