ArticleInternational journal of impotence research2026
Plaque incision and grafting for peyronie's disease: 15-year experience and functional outcomes from a high-volume andrology centre.
Article in International journal of impotence research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Plaque incision and grafting is a well-established treatment for severe or complex Peyronie's disease and preserved erectile function. This retrospective single-centre cohort study evaluated 325 patients undergoing the procedure between 2009 and 2024 at a high-volume centre. Median pre-operative curvature was 80° (IQR 60-90°) and 46.8% (152/325) had complex deformities (wasting 36.6%, hourglass 10.2%). 90.2% (293/325) completed follow-up (median 9.8 months) and were included in outcome analysis. Overall satisfaction was 87.0% (255/293), with 90.1% (264/293) resuming penetrative intercourse. Perceived length reduction occurred in 29.4% (86/293) and hypoaesthesia in 15.4% (45/293). Patients were stratified by baseline erectile status: 72.4% (212/293) had normal pre-operative erectile function and 27.6% (81/293) had pre-existing erectile dysfunction (ED). New-onset ED occurred in 22.2% (47/212) of previously potent men. Among men with pre-existing ED, 37.0% (30/81) improved and 13.6% (11/81) worsened. Multivariable regression showed cardiovascular and metabolic comorbidities were significantly associated with post-operative ED, whereas graft size and complex deformity did not. Re-operation was required in 8.5% (25/293). These findings suggest functional decline can be driven by systemic health in addition to surgical technique. Integrating cardiovascular and metabolic risk assessment into counselling is therefore essential. Management at a high-volume centre remains key to optimising outcomes.
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